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CEBPA-Associated Familial Acute Myeloid Leukemia (PDQ®): Genetics - Health Professional Information [NCI]

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Introduction and Clinical Manifestations of CEBPA-Associated Familial Acute Myeloid Leukemia (AML)

A concerted effort is being made within the genetics community to use the term, variant rather than the term, mutation to describe genetic differences in the germline. These variants can then be further classified as benign (harmless), likely benign, of uncertain significance, likely pathogenic, or pathogenic (disease causing). Throughout this summary, we will use the term, pathogenic variant to describe a disease-causing mutation. In this summary, the term, somatic mutations will be used to describe acquired genetic changes that arise in the hematopoietic system (blood stem cells and blood progenitor cells). For more information about variant classification, see the Cancer Genetics Overview summary.

The CEBPAgene is a granulocytic transcription factor (C/EBPα) that serves an important role in myeloid cell differentiation. Somatic mutations in CEBPA occur in approximately 10% to 15% of all AML cases. The presence of two somatic mutations in CEBPA (also known as CEBPAdm) is recognized as a unique clinical entity associated with favorable outcomes, even in the event of relapse.[1] Germline pathogenic variants in CEBPA were reported in 2004 in a family with hereditary, nonsyndromic AML.[2]CEBPA-associated familial AML (also known as familial AML with a CEBPA mutation) became the second autosomal dominant AML predisposition syndrome described (RUNX1-familial platelet disorder was the first).[3]

Features of CEBPA-associated familial AML include the following:

  • Highly penetrant: Unlike several other myelodysplastic syndromes (MDS)/AML predisposition syndromes, germline CEBPA pathogenic variants appear to be highly penetrant, conferring greater than a 90% lifetime risk to develop AML.[4,5,6]
  • Early-onset AML: Germline CEBPA pathogenic variants are associated with early-onset AML that can occur in childhood.[7] Published research on families with CEBPA germline pathogenic variants have reported that AML onset can occur between the ages of 1.75 to 46 years.
  • De novo AML: Inherited CEBPA pathogenic variants can predispose individuals to de novo AML without prior prolonged antecedent cytopenias or multilineage dysplasia.[2]
  • AML similar to somatic CEBPA mutation(s): The characteristics of AML arising from a germline CEBPA pathogenic variant are strikingly similar to the characteristics seen in patients with somatic CEBPA mutation(s). These include the following: normal cytogenetics, French-American-British (FAB) AML subtypes M1 and M2, numerous Auer rods seen in peripheral blood and bone marrow blasts, and aberrant CD7 expression detected by flow cytometry.[8]

References:

  1. Taskesen E, Bullinger L, Corbacioglu A, et al.: Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 117 (8): 2469-75, 2011.
  2. Smith ML, Cavenagh JD, Lister TA, et al.: Mutation of CEBPA in familial acute myeloid leukemia. N Engl J Med 351 (23): 2403-7, 2004.
  3. Johns Hopkins University: Online Mendelian Inheritance in Man: CCAAT/Enhancer-Binding Protein, Alpha; CEBPA. Johns Hopkins University, 2022. Available online. Last accessed October 9, 2023.
  4. Owen C, Barnett M, Fitzgibbon J: Familial myelodysplasia and acute myeloid leukaemia--a review. Br J Haematol 140 (2): 123-32, 2008.
  5. Pabst T, Eyholzer M, Fos J, et al.: Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. Br J Cancer 100 (8): 1343-6, 2009.
  6. Renneville A, Roumier C, Biggio V, et al.: Cooperating gene mutations in acute myeloid leukemia: a review of the literature. Leukemia 22 (5): 915-31, 2008.
  7. Tawana K, Wang J, Renneville A, et al.: Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood 126 (10): 1214-23, 2015.
  8. Nickels EM, Soodalter J, Churpek JE, et al.: Recognizing familial myeloid leukemia in adults. Ther Adv Hematol 4 (4): 254-69, 2013.

Genetics and Molecular Biology of CEBPA-Associated Familial Acute Myeloid Leukemia (AML)

The CEBPA gene is located on chromosome 19q13.1. Leukemia arising from an inherited germline CEBPApathogenic variant follows a two-hit mechanism of leukemogenesis. Germline CEBPA pathogenic variants cluster in the N-terminus (5' end) of the CEBPAgene. The second somatic mutation (at the C-terminus; 3' end) is acquired on the other CEBPAallele (in trans) when leukemia develops.[1,2] Interestingly, while the same germline pathogenic variants are present in multiple family members, individuals within families acquire distinct somatic mutations in the C-terminus region of CEBPA. In some cases, more than one C-terminus mutation can be acquired, suggesting two distinct episodes of AML in one individual.[3] Patients with CEBPA germline pathogenic variants often acquire GATA2 somatic mutations when they develop AML.[4]

The prevalence of CEBPA-associated familial AML, like that of many other inherited AML predisposition syndromes, is unknown. However, germline CEBPA pathogenic variants may account for up to 1% of all AML cases, as extrapolated from somatic testing data.[5,6] In one series, 2 of 18 patients (11%) with AML and a somatic CEBPA mutation (also called CEBPA-mutated AML) were found to carry germline pathogenic variants in the N-terminus of CEBPA.[7] In a second study, 5 of 71 patients (7%) with CEBPA-mutated AML carried a CEBPA germline pathogenic variant, suggesting that approximately 10% of individuals with biallelic CEBPA-mutated AML harbor germline pathogenic variants in CEBPA.[8] Therefore, genetic testing for CEBPA germline pathogenic variants is indicated in any patient who presents with AML and CEBPA somatic mutations (particularly biallelic CEBPA somatic mutations).

References:

  1. Leroy H, Roumier C, Huyghe P, et al.: CEBPA point mutations in hematological malignancies. Leukemia 19 (3): 329-34, 2005.
  2. Kraft IL, Godley LA: Identifying potential germline variants from sequencing hematopoietic malignancies. Blood 136 (22): 2498-2506, 2020.
  3. Sellick GS, Spendlove HE, Catovsky D, et al.: Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia. Leukemia 19 (7): 1276-8, 2005.
  4. Green CL, Tawana K, Hills RK, et al.: GATA2 mutations in sporadic and familial acute myeloid leukaemia patients with CEBPA mutations. Br J Haematol 161 (5): 701-705, 2013.
  5. Pabst T, Eyholzer M, Fos J, et al.: Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. Br J Cancer 100 (8): 1343-6, 2009.
  6. Preudhomme C, Sagot C, Boissel N, et al.: Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 100 (8): 2717-23, 2002.
  7. Pabst T, Eyholzer M, Haefliger S, et al.: Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. J Clin Oncol 26 (31): 5088-93, 2008.
  8. Taskesen E, Bullinger L, Corbacioglu A, et al.: Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 117 (8): 2469-75, 2011.

Management and Prognosis for CEBPA-Associated Familial Acute Myeloid Leukemia (AML)

CEBPA-associated familial AML is similar to sporadic AML with somatic biallelic CEBPAmutations in that both often have a favorable prognosis and preclude the need for hematopoietic stem cell transplant (HSCT). However, in individuals with AML arising from a germline CEBPApathogenic variant, the HSCT's purpose is to both treat the AML and to replace the constitutional stem cell population that harbors the AML susceptibility.[1] Like in all inherited predispositions to AML, great care needs to be taken to avoid use of a stem cell donor who carries a germline CEBPA pathogenic variant. Donor-derived leukemia has been reported in individuals with CEBPA-associated familial AML who received a transplant, unknowingly, from a donor who carried a CEBPA germline pathogenic variant.[2]

References:

  1. Stelljes M, Corbacioglu A, Schlenk RF, et al.: Allogeneic stem cell transplant to eliminate germline mutations in the gene for CCAAT-enhancer-binding protein α from hematopoietic cells in a family with AML. Leukemia 25 (7): 1209-10, 2011.
  2. Xiao H, Shi J, Luo Y, et al.: First report of multiple CEBPA mutations contributing to donor origin of leukemia relapse after allogeneic hematopoietic stem cell transplantation. Blood 117 (19): 5257-60, 2011.

Latest Updates to This Summary (12 / 14 / 2023)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

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This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® Cancer Information for Health Professionals pages.

About This PDQ Summary

Purpose of This Summary

This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about CEBPA-associated familial AML. It is intended as a resource to inform and assist clinicians in the care of their patients. It does not provide formal guidelines or recommendations for making health care decisions.

Reviewers and Updates

This summary is reviewed regularly and updated as necessary by the PDQ Cancer Genetics Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).

Board members review recently published articles each month to determine whether an article should:

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Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.

The lead reviewers for CEBPA-Associated Familial Acute Myeloid Leukemia are:

  • Julia Cooper, MS, CGC (Ohio State University)
  • Courtney DiNardo, MD, MSC (University of Texas, M.D. Anderson Cancer Center)
  • Marcin Wlodarski, MD, PhD (St. Jude Children's Research Hospital)

Any comments or questions about the summary content should be submitted to Cancer.gov through the NCI website's Email Us. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries.

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PDQ® Cancer Genetics Editorial Board. PDQ CEBPA-Associated Familial Acute Myeloid Leukemia. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: https://www.cancer.gov/publications/pdq/information-summaries/genetics/cebpa-hp-pdq. Accessed <MM/DD/YYYY>.

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Last Revised: 2023-12-14

 

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