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Botanical names:
Hoodia gordonii

Parts Used & Where Grown

Hoodia is a succulent plant that looks like a cactus. A member of the milkweed family, hoodia is native to the Kalahari desert in the southern tip of Africa, principally in the nations of South Africa and Namibia. The plant's latex and inner parts are used, with the spines removed.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
1 Star
Some clinical trials suggest hoodia may be effective at curbing appetite.
Hoodia gordonii is a succulent plant that grows in the desert in southern Africa. One small clinical trial found that hoodia latex and inner plant significantly reduced food intake. However, in a placebo-controlled trial, 1.11 grams of hoodia extract taken twice a day for 15 days had no effect on caloric intake or body weight compared with a placebo. Adverse effects of hoodia included nausea, vomiting, and increases in blood pressure and bilirubin levels (a possible indicator of liver stress). Another placebo-controlled trial found 3 grams of a frozen hoodia product taken daily for 40 days led to reduced hunger, food cravings, and self-reported food consumption, accompanied by weight loss; only mild, short-term adverse side effects were reported. More research is needed to determine if hoodia has a potential role in treating obesity.

Traditional Use (May Not Be Supported by Scientific Studies)

The San people, native to the Kalahari desert, have used hoodia for millennia to suppress appetite for food and water and to increase energy.1 They cut the spines off the plant and eat the inner portion and drink the white latex.

How It Works

Botanical names:
Hoodia gordonii

How It Works

A South African government agency, the Council for Scientific and Industrial Research (CSIR), found that a compound found only in hoodia’s latex and inner flesh, steroidal glycoside (called P57), was able to suppress appetite in animals. This effect was clearly related to effects in the brain as opposed to the stomach.2 One small clinical study has been completed by Phytopharm, a company that bought the exclusive licenses to develop and market P57 from CSIR. This study involved 19 overweight men using P57 and found that P57 did reduce their food intake significantly compared with a placebo. The details of this study have not yet been published in any medical journal, so its conclusions cannot yet be evaluated for accuracy.

How to Use It

There is no clear information on how much hoodia is necessary to reduce appetite. Anecdotal reports suggest that 2 ounces (60 grams) or more per day of the crude plant may be necessary.

Hoodia is a slow-growing plant that thrives in a relatively limited geographical area. Given the potential for becoming endangered due to high demand, there are strong regulations in place (based on the international treaty called the Convention on International Trade in Endangered Species) blocking its export. It is presently unclear if any supplements available in the US reliably contain Hoodia gordonii and how much would have to be taken of them to be useful. The Phytopharm company says they have a plantation to sustainably grow hoodia for the product they intend to release someday, but this product is not yet available.


Botanical names:
Hoodia gordonii

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Botanical names:
Hoodia gordonii

Side Effects

At the time of writing, there were no well-known side effects caused by this supplement.


1. Thompson G. Bushmen squeeze money from a humble cactus. New York Times 2003 Apr 1;Sect. A:4 (col 3).

2. MacLean DB, Luo LG. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: Studies of the anorectic mechanism of a plant steroidal glycoside. Brain Res 2004;1020:1-11.


PeaceHealth endeavors to provide comprehensive health care information, however some topics in this database describe services and procedures not offered by our providers or within our facilities because they do not comply with, nor are they condoned by, the ethics policies of our organization.