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Gamma Oryzanol


Gamma oryzanol is a naturally occurring mixture of plant chemicals called sterols and ferulic acid esters.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
300 mg daily
Supplementing with gamma oryzanol may improve improve gastritis symptoms.

The results of several clinical trials suggest that supplementation can help people with gastritis and other gastrointestinal complaints. In one study, people with chronic gastritis were given 300 mg of gamma oryzanol per day. After two weeks, 23% of people taking gamma oryzanol reported that it was “extremely effective” and 55% rated it as “moderately effective.” Another study produced similar results: People with various types of gastritis received 300 mg of gamma oryzanol per day. After two weeks, more than 62% of those with superficial gastritis, more than 87% of those with atrophic gastritis, and all people with erosive gastritis experienced improvement. These results were confirmed in a large study involving approximately 2,000 people with various gastrointestinal complaints, including several forms of gastritis. Some of these people required as much as 600 mg per day for symptoms to improve. People with gastritis wishing to take gamma oryzanol for more than six months, or in amounts exceeding 300 mg per day, should first consult with a physician.

1 Star
Athletic Performance
Refer to label instructions
Gamma oryzanol is a mixture of sterols and ferulic acid esters. One trial using ferulic acid in trained weight lifters found significantly more weight gain and increased strength compared with placebo.

is a mixture of sterols and ferulic acid esters. Despite claims that gamma oryzanol or its components increase testosterone levels, stimulate the release of endorphins, and promote the growth of lean muscle tissue, research has provided little support for these claims and has also shown gamma-oryzanol to be poorly absorbed. A recent nine-week, double-blind trial of 500 mg per day of gamma-oryzanol in weight lifters found no benefit compared with placebo in strength performance gains or circulating anabolic hormones. However, a small, double-blind trial using 30 mg per day of ferulic acid for eight weeks in trained weight lifters did find significantly more weight gain (though lean body mass was not measured) and increased strength in one of three measures compared with placebo.

How It Works

How to Use It

Much of the human research with gamma oryzanol used 300 mg per day. Healthy people do not appear to need this supplement.

Where to Find It

Gamma oryzanol is a natural component of rice bran, corn, and barley oils. Gamma oryzanol is also available as a supplement.

Possible Deficiencies

Since gamma oryzanol is not an essential nutrient, it is not associated with a deficiency state.


Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.1


1. Takemoto T, Miyoshi H, Nagashima H. Clinical trial of Hi-Z fine granules (gamma-oryzanol) on gastrointestinal symptoms at 375 hospitals (Japan). Shinyaku To Rinsho 1977;26 [in Japanese].

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How It Works

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