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Botanical names:
Smilax spp.

Parts Used & Where Grown

Many different species are called by the general name sarsaparilla. Various species are found in Mexico, South America, and the Caribbean. The root is used in herbal medicine.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
1 Star
Refer to label instructions
Sarsaparilla has been used historically to treat people with eczema.

Burdock , , red clover, and wild oats have been used historically to treat people with eczema, but without scientific investigation.

Traditional Use (May Not Be Supported by Scientific Studies)

In Mexico, sarsaparilla was used by herbalists for rheumatism, cancer, skin diseases, and a host of other conditions.1 At the turn of the 20th century, there were reports of its use by herbalists for the treatment of leprosy.2 Sarsaparilla also has a tradition of use in various women’s health concerns and was rumored to have a progesterone-like effect. Sarsaparilla was formerly a major flavoring agent in root beer.

How It Works

Botanical names:
Smilax spp.

How It Works

Sarsaparilla contains steroidal saponins, such as sarsasapogenin, which may mimic the action of some human hormones. This property remains undocumented, however. Sarsaparilla also contains phytosterols, such as beta-sitosterol, which may contribute to the anti-inflammatory effect of this herb. Reports have shown anti-inflammatory3 and liver-protecting4 effects for this herb. Similar reports on the effect of sarsaparilla on psoriasis occur in early European literature.5

How to Use It

Sarsaparilla is often taken in capsules, 2–4 grams three times per day.6 A tincture, 2–4 ml three times per day, may also be used.


Botanical names:
Smilax spp.

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

Certain medicines interact with this supplement.

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Digoxin

    Sarsaparilla may increase the absorption of digitalis and bismuth, increasing the chance of toxicity.

Explanation Required

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Botanical names:
Smilax spp.

Side Effects

According to the German Commission E monograph, sarsaparilla may cause stomach irritation and temporary kidney irritation.7 Sarsaparilla should not be taken during pregnancy or breast feeding.


1. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 446.

2. Bradley PR (ed). British Herbal Compendium, vol 1. Bournemouth, Dorset, UK: British Herbal Medicine Association, 1992, 194-6.

3. Ageel AM, Mossa JS, Al-Yahya MA, et al. Experimental studies on antirheumatic crude drugs used in Saudi traditional medicine. Drugs Exp Clin Res 1989;15:369-72.

4. Rafatullah S, Mossa JS, Ageel AM, et al. Hepatoprotective and safety evaluation studies on sarsaparilla. Int J Pharmacognosy 1991;29:296-301.

5. Hobbs C. Sarsaparilla, a literature review. HerbalGram 1988;17:1, 10-5 [review].

6. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 372-3.

7. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 372-3.

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How It Works

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