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Bitter Melon


Botanical names:
Momordica charantia

Parts Used & Where Grown

Bitter melon grows in tropical areas, including parts of East Africa, Asia, the Caribbean, and South America, where it is used as a food as well as a medicine. The fruit of this plant lives up to its name—it tastes bitter. Although the seeds, leaves, and vines of bitter melon have all been used, the fruit is the safest and most prevalent part of the plant used medicinally.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
Type 2 Diabetes
2 grams daily
Bitter melon may help lower blood glucose levels and improve overall metabolism in people with type 2 diabetes.
Bitter melon (Momordica charantia) is a common vegetable in parts of Asia and has been used historically to treat diabetes. Constituents from bitter melon were shown to have anti-inflammatory activity and the ability to inhibit enzymes needed for carbohydrate breakdown and glucose absorption in the gut. Two meta-analyses that each included four trials found bitter melon had no significant effects on HgbA1c or blood glucose levels. A more recent meta-analysis that included ten trials found positive effects on glycemic control, but noted the evidence was primarily from low-quality studies. One placebo-controlled trial with 24 participants with type 2 diabetes found taking 2,000 mg of bitter melon per day for three months resulted in reductions in weight, body fat, waist circumference, and HgbA1c, and improved blood glucose control and insulin secretion in response to glucose. A ten-week trial with 95 participants with type 2 diabetes compared bitter melon extract (2,000 mg per day) to the anti-diabetes drug glyburide (DiaBeta®, 5 mg per day); bitter melon was more effective at lowering cardiac risk but not as effective at lowering blood glucose levels.
1 Star
Indigestion, Heartburn, and Low Stomach Acidity
Refer to label instructions
Bitter melon acts as a digestive stimulant and may be helpful for indigestion.

Bitter herbs are thought to stimulate digestive function by increasing saliva production and promoting both stomach acid and digestive enzyme production. As a result, they are particularly used when there is low stomach acid but not in heartburn (where too much stomach acid could initially exacerbate the situation). These herbs literally taste bitter. Some examples of bitter herbs include greater celandine, wormwood, gentian,dandelion, blessed thistle, yarrow, devil’s claw, bitter orange, , juniper, andrographis, prickly ash, and centaury.. Bitters are generally taken either by mixing 1–3 ml tincture into water and sipping slowly 10–30 minutes before eating, or by making tea, which is also sipped slowly before eating.

Traditional Use (May Not Be Supported by Scientific Studies)

Being a relatively common food item, bitter melon was traditionally used for an array of conditions by people in tropical regions. Numerous infections, cancer, and diabetes were among the most common conditions it has been purported to improve.1 The leaves and fruit have both been used in the Western world to make teas and beer or to season soups.

How It Works

Botanical names:
Momordica charantia

How It Works

At least three different groups of constituents in bitter melon have been reported to have blood-sugar lowering actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins known as charantin, insulin-like peptides, and alkaloids. It is still unclear which of these is most effective, or if all three work together. Some clinical trials have confirmed the benefit of bitter melon for people with diabetes.2

In traditional herbal medicine, bitter melon—like other bitter-tasting herbs—is thought to stimulate digestive function and improve appetite. This has yet to be tested in human studies.

How to Use It

For those with a taste or tolerance for bitter flavor, a small melon can be eaten as food, or up to 3 1/3 ounces (100 ml) of a decoction or 2 ounces (60 ml) of fresh juice can be drunk per day.3 Though still bitter, tinctures of bitter melon (1 teaspoon [5 ml] two to three times per day) are also sometimes used. The amounts recommended would be appropriate for people with diabetes.


Botanical names:
Momordica charantia

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Botanical names:
Momordica charantia

Side Effects

Ingestion of excessive amounts of bitter melon juice (several times more than the recommended amounts) can cause abdominal pain and diarrhea.4 Excessive ingestion of the seeds had been associated with headache, fever, and coma. Bitter melon is not recommended for pregnant women. People with hypoglycemia (low blood sugar) should not take bitter melon, because it may trigger or worsen the problem. This effect has been reported in two young children and one adult patient with diabetes.


1. Duke JA. CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press, 1985, 315-6.

2. Raman A, Lau C. Anti-diabetic properties and phytochemistry of Momordica charantia L (Curcurbitaceae). Phytomed 1996;2:349-62.

3. Werbach MR, Murray MT. Botanical Influences on Illness. Tarzana, CA: Third Line Press, 1994, 139-41.

4. Brown DJ, Gaby A, Reichert R, Yarnell E. Phytotherapeutic and nutritional approaches to diabetes mellitus. Quart Rev Nat Med 1998;Winter:329-54.

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How It Works

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