Sodium Bicarbonate

Drug Information

Sodium bicarbonate (baking soda) is used as an antacid for short-term relief of stomach upset, to correct acidosis in kidney disorders, to make the urine alkaline during bladder infections, and to minimize uric acid crystallization during gout treatment. A prescription sodium bicarbonate product is given by injection to treat metabolic acidosis and some drug intoxications. Sodium bicarbonate is available as a nonprescription drug alone (sodium bicarbonate tablets) or in combination with other nonprescription drugs for short-term treatment of various conditions to treat fever and mild to moderate pain.

Summary of Interactions with Vitamins, Herbs, & Foods

What Are Nutrient Interactions
Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Folic Acid

    Folic acid is needed by the body to utilize vitamin B12. Antacids, including sodium bicarbonate, inhibit folic acid absorption. People taking antacids are advised to supplement with folic acid.

  • Iron

    In a study of nine healthy people, sodium bicarbonate administered with 10 mg of iron led to lower iron levels compared to iron administered alone. This interaction may be avoided by taking sodium bicarbonate-containing products two hours before or after iron-containing supplements.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
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