Common brand names:Eldepryl, Emsam, Zelapar
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Phenelzine has a chemical structure similar to other drugs (isoniazid and hydralazine) that can cause vitamin B6 deficiency. One case of phenelzine-induced vitamin B6 deficiency has been reported. Little is known about this interaction. People taking phenelzine should ask their doctor about monitoring vitamin B6 levels and considering supplementation.
Reduce Side Effects
Both L-tryptophan and 5-HTP have been used to treat depression. One controlled study showed that taking selegiline at the same time as 5-HTP enhanced the antidepressant effect when compared with 5-HTP alone. Further research is needed to determine whether taking selegiline and 5-HTP together might result in unwanted side effects.
Potential Negative Interaction
Ephedrine is an active ingredient found in ephedra, an herb that until 2004 was used in cold remedies and herbal weight loss products. One individual taking selegiline together with ephedrine experienced a serious side effect known as hypertensive crisis, in which blood pressure can reach dangerous levels. Though no studies have investigated whether the herb ephedra might result in similar effects, the current evidence suggests that people taking selegiline should avoid all products that contain ephedra.
Scotch broom contains high levels of tyramine. Combining phenelzine and Scotch broom may cause MAOI-type reactions (diarrhoea, flushing, sweating, pounding chest, dangerous changes in blood pressure, and other symptoms). It is important for people taking phenelzine to avoid Scotch broom. People with questions about phenelzine and Scotch broom should ask their doctor.
Rarely, people taking selegiline might experience a rapid rise in blood pressure and a severe throbbing headache when the drug is taken with foods that contain tyramine, such as cheese (especially aged); sour cream; yogurt; alcoholic beverages; meat, fish, and poultry; a variety of fruits and vegetables, including avocados, figs, and eggplant; fava beans; some soups; and chocolate. One study showed that taking 30 mg of selegiline each day greatly increases tyramine sensitivity. It has therefore been suggested that people taking 30 mg or more of selegiline per day should consume a tyramine-free diet.
Both L-tryptophan and 5-HTP have been used to treat depression. One controlled study showed that taking selegiline at the same time as 5-HTP enhanced the antidepressant effect when compared with 5-HTP alone. Further research is needed to determine whether taking selegiline and 5-HTP together might result in unwanted side effects.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Last Review: 03-18-2015
Copyright © 2023 TraceGains, Inc. All rights reserved.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The TraceGains knowledgebase does not contain every possible interaction.
The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2023.