Glipizide is a sulfonylurea drug used to lower blood sugar levels in people with type 2 (non-insulin-dependent) diabetes.
Common brand names:Glucotrol, Glucotrol XL
Summary of Interactions with Vitamins, Herbs, & Foods
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Potential Negative Interaction
In a preliminary trial, administration of Ginkgo biloba who were taking oral anti-diabetes medication resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose tolerance in individuals whose diabetes was controlled by diet. Individuals taking oral anti-diabetes medication should consult a doctor before taking Ginkgo biloba.
In a randomized study of 15 patients with type 1 (insulin-dependent) diabetes, fenugreek (Trigonella foenum-graecum) (100 grams per day for ten days) was reported to reduce blood sugar, urinary sugar excretion, serum cholesterol, and triglycerides, with no change in insulin levels, compared with ten days of placebo. In a study of 60 people with type 2 diabetes, fenugreek (25 grams per day for 24 weeks) was reported to significantly reduce blood glucose levels. People using glipizide should talk with their doctor before making any therapy changes.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Herbs such as Gymnema sylvestre will often improve blood-sugar control in diabetics.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
In a study of people with poorly controlled type 2 diabetes and low blood levels of magnesium, treatment with glipizide was associated with a significant rise in magnesium levels. In a randomized trial with eight healthy people, 850 mg magnesium hydroxide increased glipizide absorption and activity. In theory, such changes could be therapeutic or detrimental under varying circumstances. Therefore, people taking glipizide should consult with their doctor before taking magnesium supplements.
Last Review: 03-18-2015
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