Common brand names:Actifed Sinus, Benadryl Cold, Childrens Tylenol Allergy, Acetaminophen Flu Nighttime, Actifed Sinus Daytime & Night, All-Sinus-Head, Allergy Cold, Allergy Sinus Complete Caplet, Allergy Sinus Headache, Allergy Sinus Nite Caplet, Allergy-Sinus Headache, Allergy/Sinus Headache, Allergy/Sinus Nighttime Max St, Allergy/Sinus/Headache, Benadryl Allergy-Sinus-Head, Benadryl Allergy/Cold, Benadryl Allergy/Sinus/Headach, Benadryl Cold/Flu, Children's Tylenol Allergy-D, Children's Tylenol Plus, Childrens Tylenol Allergy-D, Cold Caps, Cold Control +, Complete Allergy/Sinus, CVS Night Time Flu Medicine, Decongestant Plus Cold/Flu, Diphedryl, Equate Allergy-Sinus Headache, HCA Cold Caps, Intense Cold Medicine, Intense Strength Cold Medicine, Kenahist Plus, Medi-Phedryl, Medi-Tabs Allergy Sinus, Multi-Symptom Flu Relief, Night Time, Nighttime Flu Medicine, Non-ASA Flu Nighttime Max St, Non-Aspirin Allergy Sinus Pm, Non-Aspirin Flu, Sav-on Allergy/Sinus Headache, Sudafed Sinus Nightime, Suphedrine Sinus Nighttime, Tylenol Allergy Cmpl Nighttime, Tylenol Allergy Sinus Day Time, Tylenol Allergy Sinus Night, Tylenol Flu Night Time, Tylenol Max St Flu Nighttime
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Silymarin is a collection of complex flavonoids found in milk thistle (Silybum marianum) that has been shown to elevate liver glutathione levels in rats. Acetaminophen can cause liver damage, which is believed to involve glutathione depletion. In one study involving rats, silymarin protected against acetaminophen-induced glutathione depletion. While studies to confirm this action in humans have not been conducted, some doctors recommend silymarin supplementation with 200 mg milk thistle extract, containing 70–80% silymarin, three times per day for people taking acetaminophen in large amounts for more than one year and/or with other risk factors for liver problems.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Food, especially foods high in pectin (including jellies), carbohydrates, and many types of cruciferous vegetables (broccoli, Brussels sprouts, cabbage, and others) can interfere with acetaminophen absorption. It is unclear how much effect this interaction has on acetaminophen activity.
One small study found that hibiscus could decrease levels of acetaminophen if the drug was taken after the tea was consumed though it was not entirely clear if the decreases were clinically significant.
Food, especially foods high in pectin (including jellies), carbohydrates, and many types of cruciferous vegetables (broccoli, Brussels sprouts, cabbage, and others) can interfere with acetaminophen absorption. It is unclear how much effect this interaction has on acetaminophen activity.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Potential Negative Interaction
Hospitals use oral and intravenous NAC to treat liver damage induced by acetaminophen overdose poisoning. NAC is often administered intravenously by emergency room doctors. Oral NAC appears to be effective for acetaminophen toxicity.
An uncontrolled trial compared intravenous NAC with oral NAC in children with acetaminophen poisoning and found that both methods were equally effective in reversing acetaminophen-induced liver toxicity. However, acetaminophen toxicity is a potential medical emergency, and should only be managed by qualified healthcare professionals.
Gomisin A is a constituent found in the Chinese herb schisandra (Schisandra chinensis). In a study of rats given liver-damaging amounts of acetaminophen, gomisin A appeared to protect against some liver damage but did not prevent glutathione depletion (unlike milk thistle, as reported above). Studies have not yet confirmed this action in humans.
Taking 3 grams vitamin C with acetaminophen has been shown to prolong the amount of time acetaminophen stays in the body. This theoretically might allow people to use less acetaminophen, thereby reducing the risk of side effects. Consult with a doctor about this potential before reducing the amount of acetaminophen. However, increasing the time acetaminophen is in the body might also theoretically increase its toxicity. Consult with a doctor before taking vitamin C along with acetaminophen.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Last Review: 03-24-2015
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