Skip to main content

Typical Smallpox Vaccine Reaction

Typical skin reaction at the site of a smallpox vaccine injection

Source: U.S. Centers for Disease Control and Prevention (CDC). Available online: http://www.bt.cdc.gov

The pictures show a typical reaction to the smallpox vaccine. First, a small bump (papule) forms at the vaccine site 3 to 5 days after vaccination. This becomes a pus-filled area (pustule) a few days later. The pustule dries up and then forms a scab by about 14 days after vaccination. The scab finally falls off at about 21 days after vaccination.

Current as of: July 21, 2022

Author: Healthwise Staff
Medical Review:
E. Gregory Thompson MD - Internal Medicine
Adam Husney MD - Family Medicine
Christine Hahn MD - Epidemiology

 
 

PeaceHealth endeavors to provide comprehensive health care information, however some topics in this database describe services and procedures not offered by our providers or within our facilities because they do not comply with, nor are they condoned by, the ethics policies of our organization.