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lumateperone

Pronunciation: LOO ma TE per one

Brand: Caplyta

What is the most important information I should know about lumateperone?

Lumateperone is not approved for use in older adults with dementia-related psychosis.

What is lumateperone?

Lumateperone is used to treat schizophrenia in adults.

Lumateperone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking lumateperone?

You should not use lumateperone if you are allergic to it.

Lumateperone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

  • trouble swallowing;
  • high cholesterol or triglycerides;
  • diabetes; or
  • liver disease.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking lumateperone without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.

You should not breastfeed while using lumateperone.

This medicine may affect fertility (your ability to have children), whether you are a man or a woman.

Lumateperone is not approved for use by anyone younger than 18 years old.

How should I take lumateperone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take with food.

You will need frequent medical tests.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking lumateperone?

While you are taking lumateperone, you may be more sensitive to very hot conditions. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Grapefruit may interact with lumateperone and lead to unwanted side effects. Avoid the use of grapefruit products.

What are the possible side effects of lumateperone?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use lumateperone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Call your doctor at once if you have:

  • feeling unsteady, feeling like you might pass out;
  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • tightness in your neck or throat, trouble swallowing;
  • trouble breathing or speaking;
  • a seizure;
  • high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor;
  • low white blood cell counts --fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or
  • severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • weight gain;
  • drowsiness; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lumateperone?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect lumateperone, especially:

  • an antibiotic, antifungal, or antiviral medicine;
  • blood pressure medication;
  • bronchodilator asthma medication;
  • cold or allergy medicine (Benadryl and others);
  • medicine to treat depression, anxiety, mood disorders, or mental illness;
  • medicine to treat overactive bladder;
  • medicine to treat Parkinson's disease;
  • medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;
  • seizure medicine; or
  • St. John's wort.

This list is not complete and many other drugs may affect lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about lumateperone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2020 Cerner Multum, Inc. Version: 1.01. Revision date: 2/18/2020.

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