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cladribine (injection)

Pronunciation: KLAD ri been

Brand: Leustatin

What is the most important information I should know about cladribine?

Cladribine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, cough, chest pain, mouth sores, skin sores, sore throat, trouble breathing).

Very high doses of cladribine injection can cause nerve damage or paralysis that may not be reversible. However, this effect is rare when cladribine is given in recommended doses.

What is cladribine?

Cladribine is a cancer medicine that is used to treat hairy cell leukemia (a type of blood cancer).

Cladribine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving cladribine?

You should not use cladribine if you are allergic to it.

Tell your doctor if you have ever had:

  • heart problems;
  • liver or kidney disease; or
  • weak immune system (caused by disease or by using certain medicine).

Cladribine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

You should not breastfeed while using cladribine.

How is cladribine given?

Cladribine is given as an infusion into a vein. A healthcare provider will give you this injection.

Cladribine is usually given around the clock for 7 days in a row. Your doctor will determine how many 7- day treatments you will receive and how often.

Cladribine can increase your risk of bleeding or infection. You will need frequent medical tests, and your next dose may be delayed based on the results.

If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.

What happens if I miss a dose?

Since this medication is given in a healthcare setting around the clock, you will not miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Very high doses of cladribine injection can cause nerve damage. In some people, this has resulted in loss of movement (paralysis) that may not be reversible. However, such severe symptoms are rare when cladribine is given in recommended doses. Talk with your doctor if you have concerns about this risk.

What should I avoid while receiving cladribine?

Do not receive a "live" vaccine while using cladribine, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of cladribine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • numbness, tingling, weakness, or burning pain in your fingers or toes;
  • loss of movement in any part of your body;
  • redness, swelling, or itching under your skin;
  • low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
  • kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • signs of infection --fever, chills, cough, chest pain, mouth sores, skin sores, sore throat, trouble breathing; or
  • signs of tumor cell breakdown --tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.

Common side effects may include:

  • fever;
  • nausea, vomiting, diarrhea;
  • headache, tiredness;
  • rash;
  • cough; or
  • pain, bruising, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cladribine?

Cladribine can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve).

Other drugs may affect cladribine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about cladribine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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