National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Huntington's Disease is not the name you expected.
Huntington's disease is a genetic, progressive, neurodegenerative disorder characterized by the gradual development of involuntary muscle movements affecting the hands, feet, face, and trunk and progressive deterioration of cognitive processes and memory (dementia). Neurologic movement abnormalities may include uncontrolled, irregular, rapid, jerky movements (chorea) and athetosis, a condition characterized by relatively slow, writhing involuntary movements. Dementia is typically associated with progressive disorientation and confusion, personality disintegration, impairment of memory control, restlessness, agitation, and other symptoms and findings. In individuals with the disorder, disease duration may range from approximately 10 years up to 25 years or more. Life-threatening complications may result from pneumonia or other infections, injuries related to falls, or other associated developments.
Huntington's disease is transmitted as an autosomal dominant trait. The disease results from changes (mutations) of a gene known as "huntington" located on the short arm (p) of chromosome 4 (4p16.3). In those with the disorder, the huntington gene contains errors in the coded "building blocks" (nucleotide bases) that make up the gene's instructions. The gene contains abnormally long repeats of coded instructions consisting of the basic chemicals cytosine, adenine, and guanine (CAG trinucleotide repeat expansion). The length of the expanded repeats may affect the age at symptom onset. The specific symptoms and physical features associated with Huntington's disease result from degeneration of nerve cells (neurons) within certain areas of the brain (e.g., basal ganglia, cerebral cortex).
Advocacy for Neuroacanthocytosis Patients
- 32 Launceston Place
- London, W8 5RN
- United Kingdom
- Tel: 4402079372938
- Email: firstname.lastname@example.org
- Website: http://www.naadvocacy.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Hereditary Disease Foundation, Inc.
- 3960 Broadway, 6th Floor
- New York, NY 10032
- Tel: (212)928-2121
- Fax: (212)928-2172
- Email: email@example.com
- Website: http://www.hdfoundation.org
Huntington Society of Canada
- 151 Frederick St, Suite 400
- Ontario, N2H 2M2
- Tel: 5197497063
- Fax: 5197498965
- Tel: 8009987398
- Email: firstname.lastname@example.org
- Website: http://www.huntingtonsociety.ca/english/index.asp
Huntington's Disease Society of America
- 505 Eighth Avenue
- Suite 902
- New York, NY 10018
- Tel: (212)242-1968
- Fax: (212)239-3430
- Tel: (800)345-4372
- Email: email@example.com
- Website: http://www.hdsa.org
Huntington's Disease Youth Organization
- 116 Yewdale Crescent
- CV2 2FT
- Tel: (782)179-9554
- Email: firstname.lastname@example.org
- Website: http://www.HDYO.org
March of Dimes
- 1275 Mamaroneck Avenue
- White Plains, NY 10605
- Tel: (914)997-4488
- Fax: (914)997-4763
- Email: AskUs@marchofdimes.org or email@example.com
- Website: http://www.marchofdimes.org and nacersano.org
Movement Disorder Society
- 555 E. Wells Street
- Suite 1100
- Milwaukee, WI 53202-3823
- Tel: (414)276-2145
- Fax: (414)276-3349
- Email: firstname.lastname@example.org
- Website: http://www.movementdisorders.org
NIH/National Institute of Neurological Disorders and Stroke
- P.O. Box 5801
- Bethesda, MD 20824
- Tel: (301)496-5751
- Fax: (301)402-2186
- Tel: (800)352-9424
- Website: http://www.ninds.nih.gov/
New Horizons Un-Limited, Inc.
- 811 East Wisconsin Ave
- P.O. Box 510034
- Milwaukee, WI 53203
- Tel: (414)299-0124
- Fax: (414)347-1977
- Email: email@example.com
- Website: http://www.new-horizons.org
UCSF Memory and Aging Center
- 350 Parnassus Avenue
- Suite 905
- San Francisco, CA 94117
- Tel: (415) 353-2057
- Fax: (415)476-4800
- Email: firstname.lastname@example.org
- Website: http://www.memory.ucsf.edu
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 8/15/2008
Copyright 2007 National Organization for Rare Disorders, Inc.
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