Factor VII Deficiency
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Factor VII Deficiency is not the name you expected.
Factor VII deficiency is a rare genetic bleeding disorder characterized by a deficiency or reduced activity of clotting factor VII. Clotting factors are specialized proteins that are essential for the blood to clot normally. Individuals with factor VII deficiency can experience prolonged, uncontrolled bleeding episodes. The severity of factor VII deficiency can vary greatly from one person to another. Some individuals may have no symptoms (asymptomatic); others may develop mild, moderate or potentially severe, life-threatening complications as early as in infancy. Factor VII deficiency is caused by mutations of the F7 gene and is inherited as an autosomal recessive disorder.
Factor VII deficiency was first described in the medical literature by Dr. Alexander, et al. in 1951 and was referred to as prothrombin conversion accelerator deficiency. The disorder has also been known as Alexander's disease. In extremely rare instances, factor VII deficiency can be acquired during life; this report deals with the genetic form, which is present at birth (although symptoms may develop later).
Canadian Hemophilia Society
- 301-666 Sherbrooke Street West
- Montreal, QC H3A 1E7
- Tel: 5148480503
- Fax: 5148489661
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- Website: http://www.hemophilia.ca
Children's Cancer & Blood Foundation
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Genetic and Rare Diseases (GARD) Information Center
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- Gaithersburg, MD 20898-8126
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- Website: http://rarediseases.info.nih.gov/GARD/
Hemophilia Federation of America
- 210 7th St. SE
- Suite 200B
- Washington, DC 20003
- Tel: (202)675-6984
- Fax: (202)675-6983
- Tel: (800)230-9797
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Irish Haemophilia Society
- First Floor
- Cathedral Court
- Dublin, 7
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NIH/National Heart, Lung and Blood Institute
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- Website: http://www.nhlbi.nih.gov/
National Hemophilia Foundation
- 116 West 32nd Street, 11th Floor
- New York, NY 10001
- Tel: (212)328-3700
- Fax: (212)328-3777
- Tel: (800)424-2634
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- Website: http://www.hemophilia.org
World Federation of Hemophilia
- 1425, boul. René-Lévesque O.
- Bureau 1010
- Montréal, Québec, H3G 1T7
- Tel: +1 (514) 875-7944
- Fax: +1 (514) 875-8916
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- Website: http://www.wfh.org/en/page.aspx?pid=492
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
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This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 4/24/2015
Copyright 2015 National Organization for Rare Disorders, Inc.
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