Autoimmune Polyendocrine Syndrome Type II
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Autoimmune Polyendocrine Syndrome Type II is not the name you expected.
Autoimmune polyendocrine syndrome type II, also known as Schmidt syndrome, is a rare autoimmune disorder in which there is a steep drop in production of several essential hormones by the glands that secrete these hormones. When first described, this disorder was thought to involve only adrenal insufficiency (Addison's disease) and thyroid insufficiency (Hashimoto's thyroiditis). However, over time, as more patients were studied, the scope of the disorder was expanded to include disorders of other underperforming endocrine glands. These include the gonads, which secrete sex hormones; the pancreas which secretes insulin and is intimately tied up with diabetes mellitus; and sometimes the parathyroid glands. Failure of the endocrine glands to function is usually accompanied by signs of malnutrition because the ability of the intestinal tract to absorb nutrients is reduced dramatically. Since the combination of affected glands differs from patient to patient, the signs of this disorder are diverse.
Most cases of this disorder are sporadic although some clinical researchers believe that there is a familial or hereditary trait associated with AIPS-II. If so, it may involve a complex interaction among many genes.
American Autoimmune & Related Diseases
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American Diabetes Association
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- Alexandria, VA 22311
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- Tel: (800)342-2383
- Email: askADA@diabetes.org
- Website: http://www.diabetes.org
Genetic and Rare Diseases (GARD) Information Center
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- Website: http://rarediseases.info.nih.gov/GARD/
Myasthenia Gravis Foundation of America, Inc.
- 355 Lexington Ave 15th Floor
- New York, NY 10017-6603
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NIH/National Institute of Diabetes, Digestive & Kidney Diseases
- Office of Communications & Public Liaison
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- Website: http://www2.niddk.nih.gov/
National Adrenal Diseases Foundation
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For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
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This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 7/23/2007
Copyright 2007 National Organization for Rare Disorders, Inc.
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