Staphylococcal Scalded Skin Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Staphylococcal Scalded Skin Syndrome is not the name you expected.
Staphylococcal scalded skin syndrome (SSSS) is a disorder that develops because of a toxin produced by a staphylococcal infection. A toxin is a harmful substance that causes disease when it enters tissues of the body. In SSSS the toxin specifically binds to a target protein very high in the epidermis (outer layer of the skin) producing total body reddening of the skin and blistering and sloughing of the skin resembling a hot water burn or scalding of the skin. The top layer of the skin may peel off and shed. Affected individuals may also experience nonspecific symptoms such as fever (usually low grade), chills, and weakness. Unlike similar disorders, the mucous membranes are not usually affected. Infants and younger children are most susceptible, but the disorder can also occur in certain older children or adults such as people who have compromised immune systems or insufficient kidney (renal) function. Staphylococcal scalded skin syndrome is caused by toxins produced by certain strains of a bacterial germ Staphylococcus aureus.
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This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
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Last Updated: 8/3/2015
Copyright 2015 National Organization for Rare Disorders, Inc.
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