gadobenate dimeglumine

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Pronunciation: GAD oh BEN ate dye MEG loo meen

Brand: Multihance

What is the most important information I should know about gadobenate dimeglumine?

Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

What is gadobenate dimeglumine?

Gadobenate dimeglumine is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI or MRA.

Gadobenate dimeglumine is used to help diagnose certain disorders of the brain and spine (central nervous system). This medication is also used to diagnose atherosclerosis (clogged arteries).

Gadobenate dimeglumine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving gadobenate dimeglumine?

Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

You should not receive gadobenate dimeglumine if you are allergic to it.

To make sure gadobenate dimeglumine is safe for you, tell your doctor if you have ever had:

  • any type of reaction to a contrast agent;
  • diabetes;
  • high blood pressure;
  • liver disease;
  • asthma, hay fever, food or drug allergies;
  • an injury, surgery, or severe infection; or
  • if you are over 60 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether gadobenate dimeglumine passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How should I take gadobenate dimeglumine?

Gadobenate dimeglumine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting during your MRI.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Your doctor or other healthcare provider may want to watch you for a short time after your test is over. This is to make sure you do not have any unwanted side effects or delayed reactions.

What happens if I miss a dose?

Since gadobenate dimeglumine is used only during your MRI, you will not be on a dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving gadobenate dimeglumine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of gadobenate dimeglumine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadobenate dimeglumine may occur up to several days after injection.

Gadobenate dimeglumine can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;
  • muscle weakness;
  • joint stiffness in your arms, hands, legs, or feet;
  • deep bone pain in your ribs or your hips;
  • trouble moving; or
  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems --little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
  • a seizure (convulsions);
  • pounding heartbeats or fluttering in your chest;
  • breathing problems; or
  • pain, burning, swelling, blistering, or skin changes where the injection was given.

Common side effects may include:

  • headache;
  • nausea; or
  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect gadobenate dimeglumine?

Tell your doctor about all medicines you have recently used, especially cancer medicines, such as:

  • cisplatin;
  • daunorubicin, doxorubicin;
  • etoposide;
  • methotrexate;
  • paclitaxel;
  • tamoxifen; or
  • vinblastine, vincristine.

This list is not complete. Other drugs may interact with gadobenate dimeglumine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your doctor or pharmacist can provide more information about gadobenate dimeglumine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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