levorphanol (oral)

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Pronunciation: lee VOR fa nole

Brand: Levo-Dromoran

Levorphanol 2 mg-ROX

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What is the most important information I should know about levorphanol?

Levorphanol can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

What is levorphanol?

Levorphanol is an opioid pain medication. An opioid is sometimes called a narcotic.

Levorphanol is used to treat moderate to severe pain.

Levorphanol may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking levorphanol?

You should not use levorphanol if you are allergic to it.

To make sure levorphanol is safe for you, tell your doctor if you have ever had:

  • any type of breathing problem or lung disease;
  • heart disease;
  • stomach problems;
  • liver disease;
  • a head injury, brain tumor, or seizures;
  • drug or alcohol addiction, mental illness;
  • urination problems;
  • problems with your gallbladder, adrenal gland, or thyroid; or
  • if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).

If you use levorphanol while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breast-feed while taking levorphanol. Levorphanol may cause serious side effects in the nursing baby.

Levorphanol is not approved for use by anyone younger than 18 years old.

How should I take levorphanol?

Follow all directions on your prescription label. Levorphanol can slow or stop your breathing. Never use levorphanol in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Your dose needs may be different if you are already being treated with a similar opioid medicine and your body is tolerant to it.

Levorphanol may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away levorphanol is against the law.

Do not stop using levorphanol suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using levorphanol.

Store at room temperature away from moisture and heat.

Keep track of your medicine. Levorphanol is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Never crush or break a levorphanol pill to inhale the powder or mix it into a liquid to inject the drug into your vein. Doing so could result in death.

What happens if I miss a dose?

Since levorphanol is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A levorphanol overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

What should I avoid while taking levorphanol?

Levorphanol may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Do not drink alcohol. Dangerous side effects or death could occur.

What are the possible side effects of levorphanol?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Like other narcotic medicines, levorphanol can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Stop using levorphanol and call your doctor at once if you have:

  • slow heart rate, weak pulse, weak or shallow breathing, blue lips or fingernails;
  • a light-headed feeling, like you might pass out;
  • mood changes, confusion, unusual thoughts or behavior;
  • seizure (convulsions);
  • pounding heartbeats or fluttering in your chest;
  • severe stomach pain; or
  • severe constipation, painful or difficult urination.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects may include:

  • dizziness, drowsiness, blurred vision, memory problems;
  • nausea, vomiting, dry mouth;
  • constipation;
  • itching, sweating;
  • flushing (warmth, redness, or tingly feeling); or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect levorphanol?

Taking levorphanol with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • an MAO inhibitor --isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

This list is not complete. Other drugs may interact with levorphanol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about levorphanol.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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