Nateglinide (Starlix), repaglinide (Prandin), and the
combination medicine repaglinide and metformin (Prandimet) help stop the rapid
rise in blood sugar levels that can occur immediately after a person with
type 2 diabetes eats.
How they work
Meglitinides increase the amount of
insulin produced by the
pancreas, which lowers blood sugar.
Meglitinides work quickly and do not stay in
the body long, so they need to be taken at or just before each meal.
Why they are used
Meglitinides are used to treat
type 2 diabetes in people whose blood sugar levels have not stayed within a
target range even though the people are being active and eating healthy foods.
Both meglitinides and sulfonylurea medicines increase the amount of insulin made by the pancreas, but some people have problems with weight gain and low blood sugar with sulfonylureas. Meglitinides seem to cause less weight gain and low blood sugar compared to sulfonylureas.
Because meglitinides work quickly and do not stay in the body long, they are good for people
who do not or cannot eat on the same schedule each day.
How well they work
Diabetes medicines work best for people who are being active and eating healthy foods.
Type 2 diabetes is a disease that can get worse over time, so medicines may need to change.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Usually the benefits of the medicine are more important than any minor side effects.
Side effects may go away after you take the medicine for a while.
If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.
Call 911 or other emergency services right away if you have:
Swelling of your face, lips, tongue, or throat.
Call your doctor if you have:
Cold symptoms such as a cough, runny nose, stuffy nose, or sore throat.
Common side effects of this medicine include:
Low blood sugar.
See Drug Reference for a
full list of side effects. (Drug Reference is not available in all
What to think about
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
If you are pregnant, breastfeeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breastfeeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
ByHealthwise Staff Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine Adam Husney, MD - Family Medicine Kathleen Romito, MD - Family Medicine Specialist Medical ReviewerTheresa O'Young, PharmD - Clinical Pharmacy David C.W. Lau, MD, PhD, FRCPC - Endocrinology
PeaceHealth endeavors to provide comprehensive health care information, however some topics in this database describe services and procedures not offered by our providers or within our facilities because they do not comply with, nor are they condoned by, the ethics policies of our organization.