Macrovascular complications of diabetes are those that affect the large
blood vessels. Diabetes damages the lining of blood vessels, causing them to
narrow, which decreases the blood supply and eventually causes injury to the
When blood vessels that supply the brain and
heart are affected, a stroke or heart attack may occur.
large blood vessels in the legs are affected, problems with blood circulation
to the legs and feet may develop, causing changes in skin color, decreased
sensation, and leg cramps (peripheral arterial disease).
Keeping blood sugar levels within a target blood sugar range
may help prevent macrovascular problems.
E. Gregory Thompson, MD - Internal Medicine & Adam Husney, MD - Family Medicine & David C.W. Lau, MD, PhD, FRCPC - Endocrinology
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