Zinc for Sports & Fitness

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Why Use

Zinc

Why Do Athletes Use It?*

Some athletes say that zinc helps boost the immune system and speed recovery between workouts.

What Do the Advocates Say?*

In order to repair micro tears that can occur as a result of strenuous exercise, serious athletes usually require higher amounts of most vitamins and minerals—including zinc—than sedentary people.

Zinc is essential to keeping the immune system strong. For athletes, this is especially important, since being sidelined with a viral infection, or other illness, can force one to miss valuable workout time.

Zinc deficiency is problematic as plasma testosterone is regulated in part by zinc. Therefore, a zinc deficiency may adversely affect this hormone, causing muscular mass and strength to suffer. Your doctor can administer a routine test to determine whether or not you are deficient in zinc.

*Athletes and fitness advocates may claim benefits for this supplement based on their personal or professional experience. These are individual opinions and testimonials that may or may not be supported by controlled clinical studies or published scientific articles.

Dosage & Side Effects

Zinc

How Much Is Usually Taken by Athletes?

Exercise increases zinc losses from the human body, and severe zinc deficiency can compromise muscle function.1 , 2 Athletes who do not eat an optimal diet, especially those who are trying to control their weight or use fad diets while exercising strenuously, may become deficient in zinc to the extent that performance or health is compromised.3 , 4. One double-blind trial in women found that 135 mg per day of zinc for two weeks improved one measure of muscle strength.5 Whether these women were zinc deficient was not determined in this study. A double-blind study of male athletes with low blood levels of zinc found that 20 mg per day of zinc improved the flexibility of the red blood cells during exercise, which could benefit blood flow to the muscles.6 No other studies of the effects of zinc supplementation in exercising people have been done. A safe amount of zinc for long-term use is 20 to 40 mg per day along with 1 to 2 mg of copper. Higher amounts should be taken only under the supervision of a doctor.

Side Effects

Zinc intake in excess of 300 mg per day has been reported to impair immune function.7 Some people report that zinc lozenges lead to stomach ache, nausea, mouth irritation, and a bad taste. One source reports that gastrointestinal upset, metallic taste in the mouth, blood in the urine, and lethargy can occur from chronic oral zinc supplementation over 150 mg per day,8 but those claims are unsubstantiated. In topical form, zinc has no known side effects when used as recommended.

Caution: Using zinc nasal spray has been reported to cause severe or complete loss of smell function. In some of those cases, the loss of smell was long-lasting or permanent.9

Preliminary research had suggested that people with Alzheimer’s disease should avoid zinc supplements.10 More recently, preliminary evidence in four patients actually showed improved mental function with zinc supplementation.11 In a convincing review of zinc/Alzheimer’s disease research, perhaps the most respected zinc researcher in the world concluded that zinc does not cause or exacerbate Alzheimer’s disease symptoms.12

Zinc inhibits copper absorption. Copper deficiency can result in anemia, lower levels of HDL (“good”) cholesterol, neurological disorders, and cardiac arrhythmias.13 , 14 , 15 Copper intake should be increased if zinc supplementation continues for more than a few days (except for people with Wilson’s disease).16 Some sources recommend a 10:1 ratio of zinc to copper. Evidence suggests that no more that 2 mg of copper per day is needed to prevent zinc-induced copper deficiency. Many zinc supplements include copper in the formulation to prevent zinc-induced copper deficiency. Zinc-induced copper deficiency has been reported to cause reversible anemia and suppression of bone marrow.17 In addition, there are case reports of neurologic abnormalities due to copper deficiency occurring in people who had been using large amounts of certain widely available denture creams that contained high concentrations of zinc.18

In a study of elderly people with macular degeneration, supplementing with 80 mg of zinc per day for an average of about six years increased by about 50% the incidence of hospitalizations due to genitourinary causes (such as urinary tract infections, kidney stones, and urinary retention).19 In that study, copper was also given, but in a form that cannot be absorbed by humans (cupric oxide). The reported adverse effect of zinc may have been due in large part to zinc-induced copper deficiency, which could be prevented by taking copper in a form other than cupric oxide. Nevertheless, it would be prudent for elderly people wishing to take large amounts of zinc to consult with a doctor.

Marginal zinc deficiency may be a contributing factor in some cases of anemia. In a study of women with normocytic anemia (in other words, their red blood cells were of normal size) and low total iron-binding capacity (a blood test often used to assess the cause of anemia), combined iron and zinc supplementation significantly improved the anemia, whereas iron or zinc supplemented alone had only slight effects.20 Supplementation with zinc, or zinc and iron together, has been found to improve vitamin A status among children at high risk for deficiency of the three nutrients.21

Interactions with Supplements, Foods, & Other Compounds

Zinc competes for absorption with copper, iron,22 , 23 calcium,24 and magnesium.25 A multimineral supplement will help prevent mineral imbalances that can result from taking high amounts of zinc for extended periods of time.

N-acetyl cysteine (NAC) may increase urinary excretion of zinc.26 Long-term users of NAC may consider adding supplements of zinc and copper.

Interactions with Medicines

Certain medicines interact with this supplement.

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Amlodipine-Benazepril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to benazepril) treatment led to decreased zinc levels in certain white blood cells,29 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with benazepril, until more is known, it makes sense for people taking benazepril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Aspirin

    Intake of 3 grams of aspirin per day has been shown to decrease blood levels of zinc.30 Aspirin appeared to increase loss of zinc in the urine in this study, and the effect was noted beginning three days after starting aspirin.

  • Atenolol
    Atenolol has been reported to decrease the levels of zinc in blood serum.31 The clinical significance of that finding is not certain.
  • Benazepril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to benazepril) treatment led to decreased zinc levels in certain white blood cells,33 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with benazepril, until more is known, it makes sense for people taking benazepril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Bendroflumethiazide

    Thiazide diuretics can increase urinary zinc loss.34

  • Captopril

    Preliminary research has found significant loss of zinc in urine triggered by taking captopril.42 In this trial, depletion of zinc reduced red blood cell levels of zinc. Although details remain unclear, it now appears that chronic use of captopril may lead to a zinc deficiency.43

    It makes sense for people taking captopril long term to consider taking a zinc supplement or a multimineral tablet containing zinc as a precaution. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Carbamazepine

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Chlorothiazide

    Thiazide diuretics can increase urinary zinc loss.60

  • Chlorthalidone

    Thiazide diuretics can increase urinary zinc loss.61

  • Cholestyramine

    Bile acid sequestrants may prevent absorption of folic acid and the fat-soluble vitamins A, D, E, and K.62 , 63 Other medications and vitamin supplements should be taken one hour before or four to six hours after bile acid sequestrants for optimal absorption.64 Animal studies suggest calcium and zinc may also be depleted by taking cholestyramine.65

  • Clonazepam

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Colesevelam

    Bile acid sequestrants may prevent absorption of folic acid and the fat-soluble vitamins A, D, E, and K.81 , 82 Other medications and vitamin supplements should be taken one hour before or four to six hours after bile acid sequestrants for optimal absorption.83 Animal studies suggest calcium and zinc may also be depleted by taking cholestyramine.84

  • Colestipol

    Bile acid sequestrants, including colestipol, may prevent absorption of folic acid and the fat-soluble vitamins A, D, E, K.85 , 86 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.87

    Animal studies suggest calcium and zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 88 Whether these same interactions would occur with colestipol is not known.

  • Desogestrel-Ethinyl Estradiol

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.92 , 93 , 94 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.95 , 96Oral contraceptives may interfere with manganese absorption.97 The clinical importance of these actions remains unclear.

  • Dexamethasone

    Oral corticosteroids have been found to increase urinary loss of vitamin K, vitamin C, selenium, and zinc.100 The importance of these losses is unknown.

  • Diazepam

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Divalproex

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Enalapril

    In a study of 34 people with hypertension, six months of captopril or enalapril treatment led to decreased zinc levels in certain white blood cells.119

    It makes sense for people taking enalapril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Eslicarbazepine

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Ethinyl Estradiol and Levonorgestrel

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.131 , 132 , 133 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.134 , 135Oral contraceptives may interfere with manganese absorption.136 The clinical importance of these actions remains unclear.

  • Ethinyl Estradiol and Norethindrone

    A review of literature suggests that women who use OCs may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.137 , 138 , 139 OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.140 OCs may interfere with manganese absorption.141 The clinical importance of these actions remains unclear.

  • Ethinyl Estradiol and Norgestimate

    A review of literature suggests that women who use OCs may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.142 , 143 , 144 OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.145 OCs may interfere with manganese absorption.146 The clinical importance of these actions remains unclear.

  • Ethinyl Estradiol and Norgestrel

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.147 , 148 , 149 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.150 Oral contraceptives may interfere with manganese absorption.151 The clinical importance of these actions remains unclear.

  • Ethosuximide

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Ethotoin

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Felbamate

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Folic Acid

    Though some studies indicate that supplementing with folic acid reduces blood levels of zinc, most show no interaction between the two nutrients when folic acid is taken at moderate levels.192 Therefore, until more convincing evidence is available, people taking moderate amounts of folic acid do not need to supplement with zinc. Zinc supplementation is recommended when folic acid intake is high. A doctor should be consulted to determine the appropriate time to add zinc supplementation to folic acid therapy.

  • Fosinopril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to fosinopril) treatment led to decreased zinc levels in certain white blood cells,193 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with ramipril, until more is known, it makes sense for people taking fosinopril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Fosphentyoin

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Gabapentin

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Hydrochlorothiazide

    Thiazide diuretics can increase urinary zinc loss.217

  • Hydroflumethiazide

    Thiazide diuretics can increase urinary zinc loss.219

  • Lacosamide

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Lamotrigine

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Levetiracetam

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Levonorgestrel

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.257 , 258 , 259 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.260 Oral contraceptives may interfere with manganese absorption.261 The clinical importance of these actions remains unclear.

  • Levonorgestrel-Ethinyl Estrad

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.262 , 263 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.264 , 265 Oral contraceptives may interfere with manganese absorption.266 The clinical importance of these actions remains unclear.

  • Lisinopril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to lisinopril) treatment led to decreased zinc levels in certain white blood cells,267 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with lisinopril, until more is known, it makes sense for people taking lisinopril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Losartan
    Losartan has been reported to increase urinary excretion of zinc, but the clinical significance of that finding is not certain.271
  • Mestranol and Norethindrone

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.281 , 282 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.283 , 284 Oral contraceptives may interfere with manganese absorption.285 The clinical importance of these actions remains unclear.

  • Methsuximide

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Methyclothiazide

    Thiazide diuretics can increase urinary zinc loss.296

  • Metolazone

    Thiazide diuretics can increase urinary zinc loss.11

  • Moexipril

    In a study of 34 people with hypertension, six months of captopril or enalapril treatment led to decreased zinc levels in certain white blood cells.297

    It makes sense for people taking enalapril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Norgestimate-Ethinyl Estradiol

    A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1, B2, B3, B12, C, and zinc levels.299 , 300 , 301 Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A.302 Oral contraceptives may interfere with manganese absorption.303 The clinical importance of these actions remains unclear.

  • Oxcarbazepine

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Perindopril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to perindopril) treatment led to decreased zinc levels in certain white blood cells,318 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with ramipril, until more is known, it makes sense for people taking perindopril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Phenobarbital

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Phenytoin

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Phenytoin Sodium Extended

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Phenytoin Sodium Prompt

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Polythiazide

    Thiazide diuretics can increase urinary zinc loss.350

  • Pregabalin

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Primidone

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Quinapril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to quinapril) treatment led to decreased zinc levels in certain white blood cells,373 raising concerns about possible ACE inhibitor–induced zinc depletion.

  • Ramipril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to ramipril) treatment led to decreased zinc levels in certain white blood cells,374 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with ramipril, until more is known, it makes sense for people taking ramipril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Rufinamide

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Sodium Fluoride

    Individuals who are bedridden for long periods may become deficient in zinc, which can affect the strength of bone that is formed. In a controlled study of healthy adults who were confined to bed, fluoride supplementation prevented zinc loss from the body.382 Bedridden individuals should consult a qualified healthcare practitioner for guidance in using fluoride to prevent zinc deficiency.

  • Tiagabine

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Topiramate

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Trandolapril

    In a study of 34 people with hypertension, six months of captopril or enalapril (ACE inhibitors related to trandolapril) treatment led to decreased zinc levels in certain white blood cells,403 raising concerns about possible ACE inhibitor–induced zinc depletion.

    While zinc depletion has not been reported with ramipril, until more is known, it makes sense for people taking trandolapril long term to consider, as a precaution, taking a zinc supplement or a multimineral tablet containing zinc. (Such multiminerals usually contain no more than 99 mg of potassium, probably not enough to trigger the above-mentioned interaction.) Supplements containing zinc should also contain copper, to protect against a zinc-induced copper deficiency.

  • Trichlormethiazide

    Thiazide diuretics can increase urinary zinc loss.405

  • Trimethadione

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Valproate

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Valproic Acid

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Vigabatrin

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

  • Zonisamide

    In various studies of children treated with valproic acid for epilepsy compared with control groups, serum zinc levels remained normal44 , 45 or decreased,46 serum copper levels remained normal47 , 48 or decreased,49 and red blood cell zinc levels were decreased.50 The importance of these changes and how frequently they occur remain unclear.

Reduce Side Effects

  • Busulfan

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.36 , 37 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.38

  • Capecitabine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.39 , 40 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.41

  • Carboplatin

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.51 , 52 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.53

  • Carmustine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.54 , 55 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.56

  • Chlorambucil

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.57 , 58 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.59

  • Cisplatin

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.66 , 67 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.68

  • Cladribine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.69 , 70 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.71

  • Cytarabine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.89 , 90 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.91

  • Docetaxel

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.116 , 117 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.118

  • Erlotinib

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.120 , 121 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.122

  • Etoposide

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.166 , 167 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.168

  • Floxuridine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.176 , 177 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.178

  • Fludarabine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.179 , 180 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.181

  • Hydroxyurea

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.220 , 221 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.222

  • Ifosfamide

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.223 , 224 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.225

  • Irinotecan

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.226 , 227 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.228

  • Lomustine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.268 , 269 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.270

  • Mechlorethamine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.272 , 273 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.274

  • Melphalan

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.275 , 276 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.277

  • Mercaptopurine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.278 , 279 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.280

  • Methotrexate

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.286 , 287 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.288

  • Polifeprosan 20 with Carmustine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.347 , 348 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.349

  • Thioguanine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.383 , 384 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.385

  • Thiotepa

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.386 , 387 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.388

  • Uracil Mustard

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.413 , 414 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.415

  • Vinblastine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.437 , 438 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.439

  • Vincristine

    Irradiation treatment, especially of head and neck cancers, frequently results in changes to normal taste sensation.440 , 441 Zinc supplementation may be protective against taste alterations caused or exacerbated by irradiation. A double-blind trial found that 45 mg of zinc sulfate three times daily reduced the alteration of taste sensation during radiation treatment and led to significantly greater recovery of taste sensation after treatment was concluded.442

Support Medicine

  • Alclometasone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.27 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Amcinonide

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.28 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • AZT

    A study found that adding 200 mg zinc per day to AZT treatment decreased the number of Pneumocystis carinii pneumonia and Candida infections in people with AIDS compared with people treated with AZT alone.32 The zinc also improved weight and CD4 cell levels. The amount of zinc used in this study was very high and should be combined with 1–2 mg of copper to reduce the risk of immune problems from the zinc long term.

    Preliminary human research suggests AZT therapy may cause a reduction in copper and zinc blood levels. The practical importance of these findings remains unclear.

  • Betamethasone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.35 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Clobetasol

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.72 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Clocortolone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.73 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Desonide

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.98 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Desoximetasone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.99 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Diflorasone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.108 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Erythromycin-Benzoyl Peroxide

    Using a topical zinc solution with topical erythromycin increases the effectiveness of the antibiotic in the treatment of inflammatory acne.123

  • Fluocinonide

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.182 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Flurandrenolide

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.183 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Fluticasone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.184 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Halcinonide

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.215 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Halobetasol

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.216 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Hydrocortisone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.218 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Mometasone

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.298 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

  • Prednicarbate

    Children with alopecia areata who supplemented 100 mg of zinc and 20 mg biotin each day, combined with topical clobetasol, showed more improvement compared to children who took oral corticosteroid drugs.351 Controlled research is needed to determine whether adding oral zinc and biotin to topical clobetasol therapy is more effective than clobetasol alone. However, until more information is available, caregivers should consider that children with alopecia who are currently taking oral corticosteroids might benefit from switching to supplements of zinc and biotin along with topical clobetasol.

Reduces Effectiveness

  • Alendronate

    Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed.457 Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.

  • Aminosalicylic Acid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Amoxicillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Amoxicillin–Potassium Clavulanate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ampicillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ampicillin Sodium

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ampicillin with Sulbactam

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Azithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Azithromycin Hydrogen Citrate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Aztreonam

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Aztreonam in Dextrose(IsoOsm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Bacampicillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Bacitracin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Capreomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefaclor

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefadroxil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefamandole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin in Dextrose (Iso-os)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin in Normal Saline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin Sodium-Sterile Water

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefdinir

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefditoren Pivoxil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefepime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefixime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefonicid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoperazone

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotaxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotaxime in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotetan

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotetan in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotetan in Dextrose, Iso-osm

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin in 2.2% Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin in 3.9% Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin in Dextrose, Iso-osm

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefpodoxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefprozil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftaroline Fosamil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftazidime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftazidime-Dextrose (Iso-osm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftibuten

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftizoxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftriaxone

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftriaxone-Dextrose (Iso-osm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefuroxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cephalexin HCl

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cephalothin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cephapirin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Chloramphenicol

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ciprofloxacin

    Minerals such as aluminum, calcium, copper, iron, magnesium, manganese, and zinc can bind to ciprofloxacin, greatly reducing the absorption of the drug.564 , 565 , 566 , 567 Because of the mineral content, people are advised to take ciprofloxacin two hours after consuming dairy products (milk, cheese, yogurt, ice cream, and others), antacids (Maalox®, Mylanta®, Tums®, Rolaids®, and others), and mineral-containing supplements.568

  • Ciprofloxacin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clarithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin HCl

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin Palmitate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cloxacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Colistimethate Sodium

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cycloserine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Dapsone

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Daptomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Demeclocycline

    Taking mineral supplements or antacids that contain aluminum, calcium, iron, magnesium, or zinc at the same time as tetracyclines inhibits the absorption of the drug.596 Therefore, individuals should take tetracyclines at least two hours before or after products containing minerals.

  • Dicloxacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Dirithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Doripenem

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Doxycycline

    Many minerals can decrease the absorption and reduce effectiveness of doxycycline, including calcium, magnesium, iron, zinc, and others.605 To avoid these interactions, doxycycline should be taken two hours before or two hours after dairy products (high in calcium) and mineral-containing antacids or supplements.

  • Ertapenem

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin Ethylsuccinate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin Lactobionate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin Stearate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin-Sulfisoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ethambutol

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ethionamide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Fidaxomicin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gatifloxacin

    Minerals including calcium, iron, magnesium, and zinc can bind to fluoroquinolones, including ofloxacin, greatly reducing drug absorption.569 Ofloxacin should be taken four hours before or two hours after consuming antacids (Maalox®, Mylanta®, Tumms®, Rolaids® and others) that may contain these minerals and mineral-containing supplements.570

  • Gatifloxacin in D5W

    Minerals including calcium, iron, magnesium, and zinc can bind to fluoroquinolones, including ofloxacin, greatly reducing drug absorption.569 Ofloxacin should be taken four hours before or two hours after consuming antacids (Maalox®, Mylanta®, Tumms®, Rolaids® and others) that may contain these minerals and mineral-containing supplements.570

  • Gemifloxacin

    Minerals including calcium, iron, magnesium, and zinc can bind to fluoroquinolones, including ofloxacin, greatly reducing drug absorption.569 Ofloxacin should be taken four hours before or two hours after consuming antacids (Maalox®, Mylanta®, Tumms®, Rolaids® and others) that may contain these minerals and mineral-containing supplements.570

  • Gentamicin (Pediatric)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin in Normal Saline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin in Saline (Iso-osm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin Sulfate (Ped-PF)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Imipenem-Cilastatin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Isoniazid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Isoniazid-Rifampin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Isoniazid-Rifamp-Pyrazinamide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Levofloxacin

    Minerals including calcium, iron, magnesium, and zinc can bind to fluoroquinolones, including ofloxacin, greatly reducing drug absorption.569 Ofloxacin should be taken four hours before or two hours after consuming antacids (Maalox®, Mylanta®, Tumms®, Rolaids® and others) that may contain these minerals and mineral-containing supplements.570

  • Levofloxacin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Lincomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Linezolid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Meropenem

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Mezlocillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Minocycline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Moxifloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Moxifloxacin in Saline

    Minerals including calcium, iron, magnesium, and zinc can bind to fluoroquinolones, including ofloxacin, greatly reducing drug absorption.569 Ofloxacin should be taken four hours before or two hours after consuming antacids (Maalox®, Mylanta®, Tumms®, Rolaids® and others) that may contain these minerals and mineral-containing supplements.570

  • Nafcillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Nafcillin in D2.4W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Netilmicin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Norfloxacin

    Minerals including calcium, iron, magnesium, and zinc can bind to fluoroquinolones, including ofloxacin, greatly reducing drug absorption.569 Ofloxacin should be taken four hours before or two hours after consuming antacids (Maalox®, Mylanta®, Tumms®, Rolaids® and others) that may contain these minerals and mineral-containing supplements.570

  • Ofloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Oxacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Oxacillin in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Oxytetracycline

    Many minerals can decrease the absorption of tetracycline, thus reducing its effectiveness. These minerals include aluminum (in antacids), calcium (in antacids, dairy products, and supplements), magnesium (in antacids and supplements), iron (in food and supplements), zinc (in food and supplements), and others.

  • Penicillamine

    People taking penicillamine should discuss with their doctor whether it would be appropriate to take a zinc supplement (at a separate time of day from the penicillamine).707 However, people taking penicillamine should not supplement with zinc, unless they are being supervised by a doctor.

  • Penicillin G

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Benzathine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Benzathine & Proc

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Pot in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Potassium

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Procaine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin V

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Piperacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Piperacillin-Tazobactam

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Piperacillin-Tazobactam-Dextrs

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Pyrazinamide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Quinupristin-Dalfopristin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifabutin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifampin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifapentine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifaximin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Risedronate

    Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed.457 Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.

  • Streptomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Sulfadiazine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Sulfamethoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Sulfisoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tedizolid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Telavancin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Telithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tetracycline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Thalidomide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ticarcillin-Clavulanate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tigecycline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tobramycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tobramycin Sulfate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Trimethoprim

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Trimethoprim/ Sulfamethoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Troleandomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Vancomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Vancomycin in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug458 , 459 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Warfarin

    Iron , magnesium, and zinc may bind with warfarin, potentially decreasing their absorption and activity.785 People on warfarin therapy should take warfarin and iron/magnesium/zinc-containing products at least two hours apart.

  • Zoledronic Acid-Mannitol&Water

    Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed.457 Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.

Potential Negative Interaction

  • Conjugated Estrogens

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Esterified Estrogens

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Estradiol

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Estradiol Acetate

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Estradiol Cypionate

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Estradiol Valerate

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Estradiol-Drospirenone

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Estropipate

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Ethinyl Estradiol

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Methyltestosterone

    Taking methyltestosterone increased the amount of zinc in the blood and hair of boys with short stature or growth retardation.674 It is not known whether this increase would occur in other people or whether zinc supplementation by people taking methyltestosterone would result in zinc toxicity. Until more is known, zinc supplementation should be combined with methyltestosterone therapy only under the supervision of a doctor.

  • Synthetic Conj Estrogens A

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

  • Synthetic Conj Estrogens B

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.587 The clinical significance of this interaction remains unclear.

Explanation Required

  • Calcium Acetate

    People with renal failure or on hemodialysis often have low blood levels of zinc, which may produce symptoms such as abnormal taste or smell, reduced sexual functions, and poor immunity. One controlled study showed that taking zinc at the same time as calcium acetate reduces absorption of zinc.787 Therefore, people should avoid taking calcium acetate and zinc supplements together. Another controlled study revealed that neither short-term nor long-term treatment with calcium acetate results in reduced blood zinc levels.788 Thus, while calcium acetate reduces the amount of zinc absorbed from supplements, long-term treatment with the drug does not appear to affect overall zinc status. However, people with renal failure who experience symptoms of zinc deficiency might benefit from supplementing with zinc, regardless of whether or not they take calcium acetate.

  • Methylprednisolone

    Oral corticosteroids have been found to increase urinary loss of vitamin K, vitamin C, selenium, and zinc.789 The importance of these losses is unknown.

  • Prednisolone

    Oral corticosteroids have been found to increase urinary loss of vitamin K, vitamin C, selenium, and zinc.790 The importance of these losses is unknown.

  • Prednisone

    Oral corticosteroids have been found to increase urinary loss of vitamin K, vitamin C, selenium, and zinc.791 The importance of these losses is unknown.

More Resources

Zinc

Where to Find It

Good sources of zinc include oysters, meat, eggs, seafood, black-eyed peas, tofu, and wheat germ.

Resources

See a list of books, periodicals, and other resources for this and related topics.