Magnesium for Sports & Fitness

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Why Use

Magnesium

Why Do Athletes Use It?*

Some athletes say that magnesium helps curb dehydration and prevent muscle cramping.

What Do the Advocates Say?*

People who are doing “heavy-duty” exercise lose a lot of magnesium through urination and sweat, so it’s important that it’s replaced. To keep water in the blood vessels, electrolytes, such as magnesium, need to be replaced. Therefore, to curb dehydration, electrolyte drinks are more effective than plain water.

Magnesium helps to prevent muscle cramping after exercise, too.

*Athletes and fitness advocates may claim benefits for this supplement based on their personal or professional experience. These are individual opinions and testimonials that may or may not be supported by controlled clinical studies or published scientific articles.

Dosage & Side Effects

Magnesium

How Much Is Usually Taken by Athletes?

Magnesium deficiency can reduce exercise performance and contribute to muscle cramps, but sub-optimal intake does not appear to be a problem among most groups of athletes.1 , 2 Controlled trials suggest that magnesium supplementation might improve some aspects of physiology important to sports performance in some athletes,3 , 4 but controlled and double-blind trials focusing on performance benefits of 212 to 500 mg per day of magnesium have been inconsistent.5 , 6 , 7 , 8 , 9 , 10 It is possible that magnesium supplementation benefits only those who are deficient or who are not highly trained athletes. 11 , 12

Side Effects

Comments in this section are limited to effects from taking oral magnesium. Side effects from intravenous use of magnesium are not discussed.

Taking too much magnesium often leads to diarrhea. For some people this can happen with amounts as low as 350–500 mg per day. More serious problems can develop with excessive magnesium intake from magnesium-containing laxatives. However, the amounts of magnesium found in nutritional supplements are unlikely to cause such problems. People with kidney disease should not take magnesium supplements without consulting a doctor.

Interactions with Supplements, Foods, & Other Compounds

Vitamin B6 increases the amount of magnesium that can enter cells. As a result, these two nutrients are often taken together. Magnesium may compete for absorption with other minerals. Taking a multimineral supplement avoids this potential problem.

Interactions with Medicines

Certain medicines interact with this supplement.

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Abiraterone

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Albuterol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Albuterol (Refill)

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Aldesleukin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Amifostine Crystalline

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Amphotericin B

    Amphotericin B has been reported to increase urinary excretion of magnesium.51 It remains unclear whether it is important for people taking this drug to supplement magnesium.

  • Amphotericin B Chol Sulf Cmplx

    Amphotericin B has been reported to increase urinary excretion of magnesium.51 It remains unclear whether it is important for people taking this drug to supplement magnesium.

  • Amphotericin B Lipid Complex

    Amphotericin B has been reported to increase urinary excretion of magnesium.51 It remains unclear whether it is important for people taking this drug to supplement magnesium.

  • Amphotericin B Liposome

    Amphotericin B has been reported to increase urinary excretion of magnesium.51 It remains unclear whether it is important for people taking this drug to supplement magnesium.

  • Anastrozole

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Arformoterol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Arsenic Trioxide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Asparaginase

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Axitinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Azacitidine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • BCG Live

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Belinostat

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Bendroflumethiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,109 although this deficiency may not be reflected by a low blood level of magnesium.110 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.111

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.112 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.113 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.114 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.115

  • Bexarotene

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Bicalutamide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Bleomycin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Bortezomib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Bosutinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Bumetanide

    Potassium-depleting diuretics, including loop diuretics, cause the body to lose potassium. Loop diuretics may also cause cellular magnesium depletion,155 although this deficiency may not be reflected by a low blood level of magnesium.156 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including loop diuretics, should supplement both potassium and magnesium.157

    People taking loop diuretics should be monitored by their doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.158 Fruit is high in potassium, and increasing fruit intake is another way of supplementing potassium. Magnesium supplementation is typically 300–400 mg per day.

  • Busulfan

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.161 , 162 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.163 , 164 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.165 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cabazitaxel

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cabozantinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Capecitabine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Carboplatin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.197 , 198 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.199 , 200 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.201 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Carfilzomib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Carmustine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.213 , 214 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.215 , 216 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.217 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Ceritinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cetuximab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Chlorambucil

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Chlorothiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,246 although this deficiency may not be reflected by a low blood level of magnesium.247 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.248

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.249 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.250 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.251 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.252

  • Chlorthalidone

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,253 although this deficiency may not be reflected by a low blood level of magnesium.254 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.255

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.256 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.257 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.258 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.259

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  • Cisplatin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cladribine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.277 , 278 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.279 , 280 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.281 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Clofarabine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Crizotinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cromolyn

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cycloserine

    Cycloserine may interfere with calcium and magnesium absorption.307 The clinical significance of these interactions is unclear.

    Cycloserine may interfere with the absorption and/or activity of folic acid, vitamin B6, and vitamin B12.308 , 309 The clinical importance of this interaction is unclear.

  • Cyclosporine

    Cyclosporine has been associated with low blood magnesium levels and undesirable side effects.310 , 311 , 312 Some doctors suggest monitoring the level of magnesium in red blood cells, rather than in serum, as the red blood cell test may be more sensitive for evaluating magnesium status.

  • Cytarabine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.320 , 321 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.322 , 323 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.324 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Cytarabine Liposome

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Dabrafenib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Dactinomycin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Dasatinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Daunorubicin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Daunorubicin Liposome

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Degarelix

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Denileukin Diftitox

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Desogestrel-Ethinyl Estradiol

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.383 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.384 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Dexlansoprazole
    In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole).385 Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%).386 People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.387
  • Dexrazoxane

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Docetaxel

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.409 , 410 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.411 , 412 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.413 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

    Glutathione , the main antioxidant found within cells, is frequently depleted in individuals on chemotherapy and/or radiation. Preliminary studies have found that intravenously injected glutathione may decrease some of the adverse effects of chemotherapy and radiation, such as diarrhea.414

  • Docusate

    A woman and her newborn infant experienced low blood levels of magnesium, which was possibly due to chronic use of docusate throughout and after pregnancy.415 Controlled research is necessary to determine whether people taking docusate for long periods of time need to supplement magnesium.

  • Doxorubicin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Doxorubicin Liposomal

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Enzalutamide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Epirubicin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Eribulin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Erlotinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Erythromycin

    Erythromycin may interfere with the absorption and/or activity of calcium, folic acid, magnesium, vitamin B6 and vitamin B12,463 which may cause problems, especially with long-term erythromycin treatment. Until more is known, it makes sense for people taking erythromycin for longer than two weeks to supplement with a daily multivitamin-multimineral.

  • Esomeprazole
    In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole).464 Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%).465 People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.466
  • Estradiol-Drospirenone

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.467 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.468 Although the importance of this interaction remains somewhat unclear, supplementation with 250 to 350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Estramustine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Ethinyl Estradiol and Norethindrone

    Women using OCs were found to have significantly lower serum magnesium levels in a controlled study.476 In a preliminary study, blood levels of magnesium decreased in women taking an OC containing ethinyl estradiol and levonorgestrel.477 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Ethinyl Estradiol and Norgestimate

    Women using OCs were found to have significantly lower serum magnesium levels in a controlled study.480 In a preliminary study, blood levels of magnesium decreased in women taking an OC containing ethinyl estradiol and levonorgestrel.481 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Ethinyl Estradiol and Norgestrel

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.482 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.483 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Etoposide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.491 , 492 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.493 , 494 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.495 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Etoposide Phosphate

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Everolimus

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Exemestane

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Felodipine

    Increased magnesium excretion has been observed in studies of individuals taking felodipine.517 Therefore, some physicians may recommend magnesium supplementation to their patients taking felodipine.

  • Floxuridine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Fludarabine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.538 , 539 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.540 , 541 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.542 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Fluorouracil

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Flutamide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Formoterol Fumarate

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Fulvestrant

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Furosemide

    Potassium-depleting diuretics, including loop diuretics, cause the body to lose potassium. Loop diuretics may also cause cellular magnesium depletion,570 although this deficiency may not be reflected by a low blood level of magnesium.571 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including loop diuretics, should supplement both potassium and magnesium.572

    People taking loop diuretics should be monitored by their doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.573 Fruit is high in potassium, and increasing fruit intake is another way of supplementing potassium. Magnesium supplementation is typically 300–400 mg per day.

  • Gefitinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Gemcitabine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Gentamicin

    Gentamicin has been associated with urinary loss of magnesium, resulting in hypomagnesemia (low magnesium levels) in humans.595 , 596

  • Goserelin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Hydrochlorothiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,605 although this deficiency may not be reflected by a low blood level of magnesium.606 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.607

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.608 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.609 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.610 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.611

  • Hydroflumethiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,612 although this deficiency may not be reflected by a low blood level of magnesium.613 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.614

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.615 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.616 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.617 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.618

  • Hydroxyurea

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Ibrutinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Idarubicin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Ifosfamide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.642 , 643 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.644 , 645 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.646 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Imatinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Indacaterol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Indapamide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,657 although this deficiency may not be reflected by a low blood level of magnesium.658 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.659

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.660 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.661 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.662 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.663

  • Interferon Alfa-2a

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Interferon Alfa-2B

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Irinotecan

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Irinotecan Liposomal

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Isoniazid

    Isoniazid may interfere with the activity of other nutrients, including vitamin B3 (niacin), vitamin B12, vitamin D, and vitamin E, folic acid, calcium, and magnesium.699 , 700People should consider using a daily multivitamin-mineral supplement during isoniazid therapy.

  • Ixabepilone

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Ixazomib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Kit For Indium-111-Ibritumomab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Kit For Yttrium-90-Ibritumomab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Lansoprazole
    In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole).729 Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%).730 People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.731
  • Lapatinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Lenalidomide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Lenvatinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Letrozole

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Leucovorin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Leuprolide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Leuprolide (3 Month)

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Leuprolide (4 Month)

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Leuprolide (6 Month)

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Levalbuterol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Levalbuterol Tartrate

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Levamisole

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Levoleucovorin Calcium

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Levonorgestrel-Ethinyl Estrad

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.821 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.822 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Lomustine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.825 , 826 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.827 , 828 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.829 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Mechlorethamine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.830 , 831 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.832 , 833 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.834 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Medroxyprogesterone

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Megestrol

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Melphalan

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.853 , 854 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.855 , 856 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.857 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Mercaptopurine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.865 , 866 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.867 , 868 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.869 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

    Many chemotherapy drugs can cause diarrhea, lack of appetite, vomiting, and damage to the gastrointestinal tract. Recent anti-nausea prescription medications are often effective. Nonetheless, nutritional deficiencies still occur.870 People undergoing chemotherapy should talk to their doctor about whether supplementing with a multivitamin-mineral will protect them against deficiencies.

  • Mesna

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Mestranol and Norethindrone

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.878 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.879 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Metaproterenol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Methotrexate

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.893 , 894 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.895 , 896 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.897 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Methoxsalen

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Methyclothiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,905 although this deficiency may not be reflected by a low blood level of magnesium.906 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.907

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.908 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.909 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.910 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.911

  • Metolazone

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,3 although this deficiency may not be reflected by a low blood level of magnesium.4 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.5

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.6 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.7 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.8 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.9

  • Mitomycin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Mitotane

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Mitoxantrone

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Necitumumab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Nelarabine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Neomycin

    Neomycin can decrease absorption or increase elimination of many nutrients, including calcium, carbohydrates, beta-carotene, fats, folic acid, iron, magnesium, potassium, sodium, and vitamin A, vitamin B12, vitamin D, and vitamin K.947 , 948 Surgery preparation with oral neomycin is unlikely to lead to deficiencies. It makes sense for people taking neomycin for more than a few days to also take a multivitamin-mineral supplement.

  • Nilotinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Nilutamide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Nintedanib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Norethindrone (Contraceptive)

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.970 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.971 Although the importance of this interaction remains somewhat unclear, supplementation with 250 to 350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Norethindrone Ac-Eth Estradiol

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.467 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.468 Although the importance of this interaction remains somewhat unclear, supplementation with 250 to 350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Norgestimate-Ethinyl Estradiol

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.974 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.975 Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Norgestrel

    Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study.970 In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel.971 Although the importance of this interaction remains somewhat unclear, supplementation with 250 to 350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

  • Nystatin

    Amphotericin B has been reported to increase urinary excretion of magnesium.51 It remains unclear whether it is important for people taking this drug to supplement magnesium.

  • Oxaliplatin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Paclitaxel

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Paclitaxel-Protein Bound

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Panitumumab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Panobinostat

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pantoprazole
    In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole).1018 Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%).1019 People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.1020
  • Pazopanib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pegaspargase

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Peginterferon Alfa-2b

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pemetrexed

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pentostatin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pertuzumab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pirbuterol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Plicamycin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Polifeprosan 20 with Carmustine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.1076 , 1077 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.1078 , 1079 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.1080 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Polythiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,1083 although this deficiency may not be reflected by a low blood level of magnesium.1084 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.1085

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.1086 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.1087 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.1088 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.1089

  • Pomalidomide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Ponatinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Pralatrexate

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Rabeprazole
    In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole).1123 Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%).1124 People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.1125
  • Regorafenib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Romidepsin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Salmeterol

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Samarium Sm 153 Lexidronam

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Sipuleucel-T In Lr

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Sorafenib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Sulfacetamide

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Sulfamethoxazole

    Sulfonamides, including sulfamethoxazole, can decrease absorption of calcium, magnesium, and vitamin B12.1176 This is generally not a problem when taking sulfamethoxazole for two weeks or less. People taking sulfamethoxazole for longer than two weeks should ask their doctor about nutrient monitoring and supplementation.

    Note: Since sulfamethoxazole is often prescribed in combination with trimethoprim (for example, in Bactrim or Septra), it may be easy to associate this interaction with trimethoprim. However, this interaction is not known to occur with trimethoprim alone.

  • Sunitinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Tamoxifen

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Temsirolimus

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • TeniposIde

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Terbutaline

    Therapeutic amounts of intravenous salbutamol (albuterol) in four healthy people were associated with decreased plasma levels of calcium, magnesium, phosphate, and potassium.25 Decreased potassium levels have been reported with oral,26 intramuscular, and subcutaneous albuterol administration.27 How frequently this effect occurs is not known; whether these changes are preventable through diet or supplementation is also unknown.

  • Testolactone

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Theophylline

    Preliminary evidence indicates that theophylline can promote potassium and magnesium deficiency.1220 , 1221 Some doctors have noted a tendency for persons on theophylline to become deficient in these minerals. Therefore, supplementing with these minerals may be necessary during theophylline therapy. Consult with a doctor to make this determination.

  • Thioguanine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.1229 , 1230 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.1231 , 1232 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.1233 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Thiotepa

    Cisplatin may cause excessive loss of magnesium and potassium in the urine.1236 , 1237 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.1238 , 1239 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.1240 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Tobramycin

    Calcium , magnesium, and potassium depletion requiring prolonged replacement were reported in a child with tetany who had just completed a three-week course of i.v. tobramycin.1241 The authors suggest this may have been due to kidney damage related to the drug. Seventeen patients with cancer developed calcium, magnesium, and potassium depletion after treatment with aminoglycoside antibiotics, including tobramycin.1242 The authors suggested a possible potentiating action of tobramycin-induced mineral depletion by chemotherapy drugs, especially doxorubicin (Adriamycin®).

    Until more is known, people receiving i.v. tobramycin should ask their doctor about monitoring calcium, magnesium, and potassium levels and the possibility of mineral replacement.

  • Topotecan

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Toremifene

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Torsemide

    Potassium-depleting diuretics, including loop diuretics, cause the body to lose potassium. Loop diuretics may also cause cellular magnesium depletion,1257 although this deficiency may not be reflected by a low blood level of magnesium.1258 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including loop diuretics, should supplement both potassium and magnesium.1259

    People taking loop diuretics should be monitored by their doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.1260 Fruit is high in potassium, and increasing fruit intake is another way of supplementing potassium. Magnesium supplementation is typically 300–400 mg per day.

  • Trametinib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Trastuzumab

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Tretinoin (Chemotherapy)

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Trichlormethiazide

    Potassium-depleting diuretics, including thiazide diuretics, cause the body to lose potassium; they may also cause cellular magnesium depletion,1291 although this deficiency may not be reflected by a low blood level of magnesium.1292 Magnesium loss induced by potassium-depleting diuretics can cause additional potassium loss. Until more is known, it has been suggested that people taking potassium-depleting diuretics, including thiazide diuretics, should supplement both potassium and magnesium.1293

    People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease. In a preliminary study, people with low blood levels of potassium (in part related to diuretic use) had a higher incidence of serious problems resulting from surgery (including death) compared with those having normal potassium levels.1294 A double-blind trial showed that thiazide diuretic use led to a reduction in blood levels of potassium in some participants. Those experiencing decreased potassium levels were also more likely to experience cardiovascular events, such as heart attacks, stroke, heart failure, aneurysm, and sudden cardiac death.1295 Fruit is high in potassium, and increasing fruit intake (especially bananas) is another way of supplementing potassium.

    Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides.1296 Combining supplementation of both potassium and magnesium has been reported to correct abnormally low blood levels of potassium and also to protect against excessive loss of magnesium.1297

  • Trimethoprim/ Sulfamethoxazole

    Sulfonamides, including sulfamethoxazole, can decrease absorption of calcium, magnesium, and vitamin B12.1298 This is generally not a problem when taking sulfamethoxazole for two weeks or less. People taking sulfamethoxazole for longer than two weeks should ask their doctor about nutrient monitoring and supplementation.

  • Triptorelin Pamoate

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Uracil Mustard

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.1308 , 1309 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.1310 , 1311 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.1312 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Valrubicin

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Vandetanib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Vemurafenib

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Vinblastine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Vincristine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Vincristine Sulfate Liposomal

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

  • Vinorelbine

    The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine.15 , 16 Preliminary reports suggest that both potassium and magnesium supplementation may be necessary to increase low potassium levels.17 , 18 Severe magnesium deficiency caused by cisplatin therapy has been reported to result in seizures.19 Severe magnesium deficiency is a potentially dangerous medical condition that should only be treated by a doctor. People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status.

Reduce Side Effects

  • Abiraterone
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ado-Trastuzumab Emtansine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Aldesleukin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Alemtuzumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Altretamine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Amifostine Crystalline
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Anastrozole
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Arsenic Trioxide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Asparaginase
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Axitinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Azacitidine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • BCG Live
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Belinostat
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bendamustine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bevacizumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bexarotene
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bicalutamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bleomycin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bortezomib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Bosutinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Brentuximab Vedotin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Busulfan
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cabazitaxel
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cabozantinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Capecitabine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Carboplatin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Carfilzomib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Carmustine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ceritinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cetuximab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Chlorambucil
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cisplatin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cladribine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Clofarabine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Crizotinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cromolyn
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cyclophosphamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cytarabine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Cytarabine Liposome
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Dabrafenib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Dacarbazine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Dactinomycin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Dasatinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Daunorubicin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Daunorubicin Liposome
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Degarelix
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Denileukin Diftitox
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Dexrazoxane
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Digoxin

    People taking potassium-depleting diuretics may develop low potassium and magnesium blood levels. Prolonged diarrhea and vomiting might also result in low blood potassium levels. People with low potassium or magnesium blood levels who take quinidine might develop serious drug side effects.399 Therefore, people taking quinidine should have their blood potassium and magnesium levels checked regularly and might need to supplement with both minerals, especially when taking potassium-depleting diuretics.

  • Disopyramide

    Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.400 , 401 Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.

  • Docetaxel
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Doxorubicin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Doxorubicin Liposomal
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Enzalutamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Epirubicin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Eribulin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Erlotinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Estramustine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Etoposide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Etoposide Phosphate
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Everolimus
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Exemestane
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Floxuridine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Fludarabine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Fluorouracil
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Flutamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Fulvestrant
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Gefitinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Gemcitabine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Goserelin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Hydroxyurea
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ibrutinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Idarubicin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ifosfamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Imatinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Interferon Alfa-2a
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Interferon Alfa-2B
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ipilimumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Irinotecan
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Irinotecan Liposomal
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ixabepilone
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ixazomib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Kit For Indium-111-Ibritumomab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Kit For Yttrium-90-Ibritumomab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Lapatinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Lenalidomide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Lenvatinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Letrozole
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Leucovorin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Leuprolide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Leuprolide (3 Month)
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Leuprolide (4 Month)
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Leuprolide (6 Month)
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Levamisole
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Levoleucovorin Calcium
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Lomustine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Mechlorethamine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Medroxyprogesterone
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Megestrol
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Melphalan
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Mercaptopurine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Mesna
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Methotrexate
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Methoxsalen
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Mitomycin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Mitotane
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Mitoxantrone
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Necitumumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Nelarabine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Nilotinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Nilutamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Nintedanib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Obinutuzumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ofatumumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Oxaliplatin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Paclitaxel
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Paclitaxel-Protein Bound
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Panitumumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Panobinostat
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pazopanib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pegaspargase
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Peginterferon Alfa-2b
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pemetrexed
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pentostatin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pertuzumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Plicamycin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Polifeprosan 20 with Carmustine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pomalidomide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Ponatinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Pralatrexate
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Procainamide

    Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.400 , 401 Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.

  • Procarbazine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Quinidine

    Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.400 , 401 Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.

  • Quinidine Gluconate

    Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.400 , 401 Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.

  • Quinidine Polygalacturonate

    Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.400 , 401 Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.

  • Regorafenib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Rituximab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Romidepsin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Samarium Sm 153 Lexidronam
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Sipuleucel-T In Lr
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Sorafenib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Sulfacetamide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Sunitinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Tamoxifen
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Temozolomide
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Temsirolimus
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • TeniposIde
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Testolactone
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Thioguanine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Thiotepa
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Topotecan
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Toremifene
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Trametinib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Trastuzumab
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Tretinoin (Chemotherapy)
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Triptorelin Pamoate
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Uracil Mustard
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Valrubicin
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Vandetanib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Vemurafenib
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Vinblastine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Vincristine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Vincristine Sulfate Liposomal
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.
  • Vinorelbine
    In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.13 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.14 It is not known whether oral administration of these minerals would also be beneficial.

Support Medicine

  • Digoxin

    People needing digoxin may have low levels of potassium or magnesium,395 increasing the risk for digoxin toxicity. Digoxin therapy may increase magnesium elimination from the body.396 People taking digoxin may benefit from magnesium supplementation.397 Medical doctors do not commonly check magnesium status, and when they do, they typically use an insensitive indicator of magnesium status (serum or plasma levels). The red blood cell magnesium level may be a more sensitive indicator of magnesium status, although evidence is conflicting. It has been suggested that 300–500 mg of magnesium per day is a reasonable amount to supplement.398

  • Fentanyl

    One double-blind study showed that giving magnesium intravenously before surgery dramatically reduced the amount of fentanyl needed to control pain during and after an operation.518 Further research is needed to determine whether people using fentanyl patches might benefit from supplementing with oral magnesium.

  • Glimepiride

    Supplementing magnesium may enhance the blood-sugar-lowering effects of sulfonylurea drugs.597 Though no current studies have investigated whether glimepiride increases the risk of developing hypoglycemia, individuals should closely monitor their blood glucose while taking glimepiride together with magnesium supplements.

Reduces Effectiveness

  • Aminosalicylic Acid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Amoxicillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Amoxicillin–Potassium Clavulanate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ampicillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ampicillin Sodium

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ampicillin with Sulbactam

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Atorvastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Azithromycin

    A magnesium- and aluminum-containing antacid was reported to interfere with azithromycin absorption in a study of ten healthy people.1397 People can avoid this interaction by taking azithromycin two hours before or after any aluminum/magnesium-containing products. It has not yet been shown that magnesium compounds typically found in supplements affect absorption of this drug.

  • Azithromycin Hydrogen Citrate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Aztreonam

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Aztreonam in Dextrose(IsoOsm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Bacampicillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Bacitracin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Capreomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefaclor

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefadroxil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefamandole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin in Dextrose (Iso-os)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin in Normal Saline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefazolin Sodium-Sterile Water

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefdinir

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefditoren Pivoxil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefepime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefixime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefonicid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoperazone

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotaxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotaxime in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotetan

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotetan in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefotetan in Dextrose, Iso-osm

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin in 2.2% Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin in 3.9% Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefoxitin in Dextrose, Iso-osm

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefpodoxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefprozil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftaroline Fosamil

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftazidime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftazidime-Dextrose (Iso-osm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftibuten

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftizoxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftriaxone

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ceftriaxone-Dextrose (Iso-osm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cefuroxime

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cephalexin HCl

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cephalothin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cephapirin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cerivastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Chloramphenicol

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cimetidine

    In healthy volunteers, a magnesium hydroxide/aluminum hydroxide antacid, taken with cimetidine, decreased cimetidine absorption by 20 to 25%.1490 People can avoid this interaction by taking cimetidine two hours before or after any aluminum/magnesium-containing antacids, including magnesium hydroxide found in some vitamin/mineral supplements. However, the available studies do not clearly indicate if magnesium hydroxide was the problem and may not need to be avoided.

  • Cimetidine in Normal Saline

    In healthy people, a magnesium hydroxide/aluminum hydroxide antacid, taken with nizatidine, decreased nizatidine absorption by 12%.1491 People can avoid this interaction by taking nizatidine two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Ciprofloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ciprofloxacin in D5W

    Taking magnesium supplements at the same time as levofloxacin can reduce the intestinal absorption—and thus the effectiveness—of the drug.1501 Consequently, nutritional supplements or antacids containing magnesium, if used, should be taken two hours before or after taking levofloxacin.

  • Clarithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin HCl

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Clindamycin Palmitate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cloxacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Colistimethate Sodium

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Cycloserine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Dapsone

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Daptomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Demeclocycline

    Taking mineral supplements or antacids that contain aluminum, calcium, iron, magnesium, or zinc at the same time as tetracyclines inhibits the absorption of the drug.1524 Therefore, individuals should take tetracyclines at least two hours before or after products containing minerals.

  • Dicloxacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Dirithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Doripenem

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Doxycycline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ertapenem

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin Ethylsuccinate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin Lactobionate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin Stearate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Erythromycin-Sulfisoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ethambutol

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ethionamide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Famotidine

    In healthy people, a magnesium hydroxide/aluminum hydroxide antacid, taken with famotidine, decreased famotidine absorption by 20–25%.1552 People can avoid this interaction by taking famotidine two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Famotidine (PF)

    In healthy people, a magnesium hydroxide/aluminum hydroxide antacid, taken with nizatidine, decreased nizatidine absorption by 12%.1491 People can avoid this interaction by taking nizatidine two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Famotidine in Normal Saline

    In healthy people, a magnesium hydroxide/aluminum hydroxide antacid, taken with nizatidine, decreased nizatidine absorption by 12%.1491 People can avoid this interaction by taking nizatidine two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Fidaxomicin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Fluvastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Folic Acid

    One controlled study showed that taking folic acid together with an antacid containing aluminum and magnesium hydroxide reduced the absorption of the vitamin.1558 Therefore, individuals should take folic acid one hour before or two hours after taking antacids containing aluminum and magnesium hydroxide.

  • Gatifloxacin

    Taking magnesium supplements at the same time as levofloxacin can reduce the intestinal absorption—and thus the effectiveness—of the drug.1501 Consequently, nutritional supplements or antacids containing magnesium, if used, should be taken two hours before or after taking levofloxacin.

  • Gatifloxacin in D5W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gemifloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin (Pediatric)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin in Normal Saline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin in Saline (Iso-osm)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Gentamicin Sulfate (Ped-PF)

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Hydroxychloroquine

    Magnesium supplementation may reduce blood levels of chloroquine, a compound similar to hydroxychloroquine, and decrease its effectiveness.1576 Until more is known, people taking hydroxychloroquine for arthritis who are also using magnesium supplements and are not experiencing relief might try avoiding the supplements or taking them at separate times.

  • Imipenem-Cilastatin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Isoniazid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Isoniazid-Rifampin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Isoniazid-Rifamp-Pyrazinamide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Levofloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Levofloxacin in D5W

    Taking magnesium supplements at the same time as levofloxacin can reduce the intestinal absorption—and thus the effectiveness—of the drug.1501 Consequently, nutritional supplements or antacids containing magnesium, if used, should be taken two hours before or after taking levofloxacin.

  • Lincomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Linezolid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Lovastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Meropenem

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Mezlocillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Minocycline

    Many minerals can decrease the absorption of tetracycline, thus reducing its effectiveness. These minerals include aluminum (in antacids), calcium (in antacids, dairy products, and supplements), magnesium (in antacids and supplements), iron (in food and supplements), zinc (in food and supplements), and others.

  • Moxifloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Moxifloxacin in Saline

    Taking magnesium supplements at the same time as levofloxacin can reduce the intestinal absorption—and thus the effectiveness—of the drug.1501 Consequently, nutritional supplements or antacids containing magnesium, if used, should be taken two hours before or after taking levofloxacin.

  • Nafcillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Nafcillin in D2.4W

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Nitrofurantoin

    In six healthy men, nitrofurantoin absorption was reduced by also taking magnesium trisilicate.1612 Another magnesium compound, magnesium oxide (commonly found in supplements) was shown to bind with nitrofurantoin in a test tube.1613

    In a study of 11 people, the rate of nitrofurantoin absorption was delayed despite the fact that the amount of nitrofurantoin ultimately absorbed remained the same when the drug was administered in a colloidal magnesium aluminum silicate suspension.1614 It remains unclear whether this interaction is clinically important or if typical magnesium supplements would have the same effect.

  • Nizatidine

    In healthy people, a magnesium hydroxide/aluminum hydroxide antacid, taken with nizatidine, decreased nizatidine absorption by 12%.1491 People can avoid this interaction by taking nizatidine two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Norfloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ofloxacin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Oxacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Oxacillin in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Oxytetracycline

    Many minerals can decrease the absorption of tetracycline, thus reducing its effectiveness. These minerals include aluminum (in antacids), calcium (in antacids, dairy products, and supplements), magnesium (in antacids and supplements), iron (in food and supplements), zinc (in food and supplements), and others.

  • Penicillin G

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Benzathine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Benzathine & Proc

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Pot in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Potassium

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin G Procaine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Penicillin V

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Piperacillin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Piperacillin-Tazobactam

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Piperacillin-Tazobactam-Dextrs

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Pitavastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Pravastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Pyrazinamide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Quinupristin-Dalfopristin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ranitidine

    In healthy people, a magnesium hydroxide/aluminum hydroxide antacid, taken with nizatidine, decreased nizatidine absorption by 12%.1491 People can avoid this interaction by taking nizatidine two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Rifabutin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifampin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifapentine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rifaximin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Rosuvastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Simvastatin

    A magnesium- and aluminum-containing antacid was reported to interfere with atorvastatin absorption.1394 People can avoid this interaction by taking atorvastatin two hours before or after any aluminum/magnesium-containing antacids. Some magnesium supplements such as magnesium hydroxide are also antacids.

  • Sulfadiazine

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Sulfamethoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Sulfisoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tedizolid

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Telavancin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Telithromycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tetracycline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Thalidomide

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Ticarcillin-Clavulanate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tigecycline

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Tobramycin Sulfate

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Trimethoprim

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Trimethoprim/ Sulfamethoxazole

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Troleandomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Vancomycin

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Vancomycin in Dextrose

    Taking calcium, iron, magnesium, or zinc at the same time as minocycline can decrease the absorption of both the drug1382 , 1383 and the mineral. Therefore, calcium, iron, magnesium, or zinc supplements, if used, should be taken an hour before or after the drug.

  • Warfarin

    Iron , magnesium, and zinc may bind with warfarin, potentially decreasing their absorption and activity.1707 People on warfarin therapy should take warfarin and iron/magnesium/zinc-containing products at least two hours apart.

Potential Negative Interaction

  • Amiloride

    Preliminary research in animals suggests that amiloride may reduce the urinary excretion of magnesium.1381 It is unknown if this same effect would occur in humans. Nevertheless, persons taking more than 300 mg of magnesium per day and amiloride should consult with a doctor, as this combination may lead to potentially dangerous elevations in levels of magnesium in the body. The combination of amiloride and hydrochlorothiazide would likely eliminate this problem, as hydrochlorothiazide may deplete magnesium.

  • Calcium Acetate

    Calcium-containing antacids, when taken together with calcium acetate, may result in abnormally high blood levels of calcium.1408 Consequently, people taking calcium acetate should avoid taking calcium-containing antacids.

  • Dexamethasone

    Corticosteroids may increase the body’s loss of magnesium.1525 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1526

  • Misoprostol

    A common side effect of misoprostol is diarrhea, which is aggravated by taking magnesium.1601 Consequently, individuals who experience diarrhea while taking misoprostol should avoid magnesium supplementation.

  • Spironolactone

    Preliminary research in animals suggests that amiloride, a drug similar to spironolactone, may inhibit the urinary excretion of magnesium.1673 It is unknown if this same effect would occur in humans or with spironolactone. Persons taking more than 300 mg of magnesium per day and spironolactone should consult with a doctor as this combination may lead to potentially dangerous increases in the level of magnesium in the body. The combination of spironolactone and hydrochlorothiazide would likely eliminate this problem, as hydrochlorothiazide may deplete magnesium.

  • Triamterene

    Preliminary research in animals suggests that triamterene may inhibit the urinary excretion of magnesium.1696 It is unknown if this same effect would occur in humans. Persons taking more than 300 mg of magnesium per day and triamterene should consult with a doctor as this combination may lead to potentially dangerous increases in the level of magnesium in the body. The combination of triamterene and hydrochlorothiazide would likely eliminate this problem, as hydrochlorothiazide may deplete magnesium.

Explanation Required

  • Alendronate

    Absorption of tiludronate, a drug related to alendronate, is reduced when taken with magnesium and/or aluminum-containing antacids.1708 This interaction has not yet been reported with alendronate. Until more is known, alendronate should be taken two hours before or after magnesium and/or aluminum-containing antacids.

  • Cortisone

    Corticosteroids may increase the body’s loss of magnesium.1709 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1710

  • Dexamethasone Sod Phosphate-PF

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Dexamethasone Sodium Phosphate

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Epinephrine

    Intravenous administration of epinephrine to human volunteers reduced plasma concentrations of vitamin C.1715 Epinephrine and other “stress hormones” may reduce intracellular concentrations of potassium and magnesium.1716 Although there are no clinical studies in humans, it seems reasonable that individuals using epinephrine should consume a diet high in vitamin C, potassium, and magnesium, or should consider supplementing with these nutrients.

  • Etidronate

    Absorption of tiludronate, a drug related to alendronate, is reduced when taken with magnesium and/or aluminum-containing antacids.1717 This interaction has not yet been reported with alendronate. Until more is known, alendronate should be taken two hours before or after magnesium and/or aluminum-containing antacids.

  • Glipizide

    In a study of people with poorly controlled type 2 diabetes and low blood levels of magnesium, treatment with glipizide was associated with a significant rise in magnesium levels.1718 In a randomized trial with eight healthy people, 850 mg magnesium hydroxide increased glipizide absorption and activity.1719 In theory, such changes could be therapeutic or detrimental under varying circumstances. Therefore, people taking glipizide should consult with their doctor before taking magnesium supplements.

  • Hydrocortisone

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Hydrocortisone Acetate

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Hydrocortisone Sod Succinate

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Hydromorphone

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Medroxyprogesterone

    In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion.1728 The clinical significance of this interaction remains unclear.

  • Metformin

    In a study of patients with poorly controlled type 2 diabetes, low blood levels of magnesium, and high urine magnesium loss, metformin therapy was associated with reduced urinary magnesium losses but no change in low blood levels of magnesium.1729 Whether this interaction has clinical importance remains unclear.

  • Methylprednisolone

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Methylprednisolone Acetate

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Methylprednisolone Sodium Succ

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Omeprazole
    In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole).1736 Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%).1737 People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.1738
  • Pamidronate

    Absorption of tiludronate, a drug related to alendronate, is reduced when taken with magnesium and/or aluminum-containing antacids.1739 This interaction has not yet been reported with alendronate. Until more is known, alendronate should be taken two hours before or after magnesium and/or aluminum-containing antacids.

  • Prednisolone

    Corticosteroids may increase the body’s loss of magnesium.1742 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300 to 400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1743

  • Prednisolone Acetate

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Prednisolone Sodium Phosphate

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Prednisone

    Corticosteroids may increase the body’s loss of magnesium.1750 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1751

  • Risedronate

    Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed.1752 Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.

  • Triamcinolone

    Corticosteroids may increase the body’s loss of magnesium.1711 Some doctors recommend that people taking corticosteroids for more than two weeks supplement with 300–400 mg of magnesium per day. Magnesium has also been reported to interfere with the absorption of dexamethasone.1712

  • Troleandomycin

    A magnesium- and aluminum-containing antacid was reported to interfere with absorption of azithromycin, another macrolide drug, in a study of ten healthy people.1755 People can avoid this interaction by taking azithromycin two hours before or after any aluminum/magnesium-containing products. It has not yet been shown that magnesium compounds typically found in supplements affect absorption of azithromycin or other similar drugs.

More Resources

Magnesium

Where to Find It

Nuts and grains are good sources of magnesium. Beans, dark green vegetables, fish, and meat also contain significant amounts.

Resources

See a list of books, periodicals, and other resources for this and related topics.