Uses

Lipase is an enzyme that is used by the body to break down dietary fats into an absorbable form.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
3 Stars
Cystic Fibrosis
Up to 10,000 IU daily per 2.2 lbs (1 kg) body weight or 500 to 1,000 lipase units per gram of fat consumed in the diet
People with cystic fibrosis tend to have insufficient pancreas function. Supplementing with pancreatic enzymes will often lead to improved digestion, especially of fats.

People with CF tend to have insufficient pancreas function. Supplementation with pancreatic enzymes will often lead to improved digestion, especially of fats. The current recommendation for people with cystic fibrosis is to supplement with pancreatic enzymes at meals. Amounts should not exceed 10,000 IU of lipase per day per 2.2 pounds body weight or 500 to 1,000 lipase units per gram of dietary fat consumed, as larger amounts may damage the large intestine. A double-blind trial found enteric-coated microsphere enzyme preparations to be superior to enteric-coated capsules for reduction of abdominal pain and improvement of digestion.Because pancreatin is rapidly emptied from the stomach during digestion, people taking these enzymes may obtain better results by spreading supplementation throughout the meal.

1 Star
Celiac Disease
Refer to label instructions
Lipase may be beneficial for people who do not produce adequate digestive secretions from the pancreas, a common occurrence with celiac disease.

People with celiac disease often do not produce adequate digestive secretions from the pancreas, including lipase enzymes In a double-blind trial, children with celiac disease who received a pancreatic enzyme supplement along with a gluten-free diet gained significantly more weight in the first month than those treated with only a gluten-free diet. However, this benefit disappeared in the second month, suggesting enzyme supplements may only be useful at the beginning of dietary treatment.

1 Star
Crohn's Disease
Refer to label instructions
People with Crohn's disease may be deficient in lipase. Supplementing with enzymes might improve the malabsorption that is associated with the disease.

People with Crohn's disease may be deficient in pancreatic enzymes, including lipase. In theory, supplementing with enzymes might improve the nutrient malabsorption that is often associated with Crohn's disease. However, people with Crohn's disease considering supplementation with enzymes should consult a doctor.

How It Works

How to Use It

Products that contain lipase also usually contain other enzymes that help digest carbohydrates and protein. In the U.S., pancreatin, which contains lipase, amylase, and proteases, is rated against a government standard. For example, "9X pancreatin" is nine times stronger than the government standard. Each "X" contains 25 USP units of amylase, 2 USP units of lipase, and 25 USP units of proteolytic enzymes. Taking 1.5 grams of 9X pancreatin (or a higher amount at lower potencies) with each meal can help people with pancreatic insufficiency digest food.

Where to Find It

Most of the body's lipase is manufactured in the pancreas, although some of it is secreted in the saliva, as well. Pancreatin contains lipase along with two other groups of enzymes: proteases and amylase.

Possible Deficiencies

People with pancreatic insufficiency and cystic fibrosis frequently require supplemental lipase and other enzymes. In addition, those with celiac disease1 or Crohn's disease2 and perhaps some people suffering from indigestion3 may be deficient in pancreatic enzymes including lipase.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

At the time of writing, there were no well-known side effects caused by this supplement.

References

1. Patel RS, Johlin FC Jr, Murray JA. Celiac disease and recurrent pancreatitis. Gastrointest Endosc 1999;50:823-7.

2. Hegnhoj J, Hansen CP, Rannem T, et al. Pancreatic function in Crohn's disease. Gut 1990;31:1076-9.

3. Suarez F, Levitt MD, Adshead J, Barkin JS. Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal. Dig Dis Sci 1999;44:1317-21.