DMAE (2-dimethylaminoethanol) is a chemical produced in the brain.
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DMAE (2-dimethylaminoethanol) may increase levels of a brain neurotransmitter, which may foster positive behavior changes in people with dementia.
DMAE (2-dimethylaminoethanol) may increase levels of the brain neurotransmitter acetylcholine. In one preliminary trial, people with senile dementia were given DMAE supplements of 600 mg three times per day for four weeks. The participants did not show any changes in memory, though some did show positive behavior changes.1 However, a subsequent double-blind trial found no significant benefit from DMAE supplementation in people with Alzheimer’s disease.2
Refer to label instructions
Taking dimethylaminoethanol may help reduce symptoms.
Dimethylaminoethanol (DMAE) is a natural choline precursor. Although some preliminary data suggested that DMAE could decrease TD symptoms,3 most studies show that DMAE is no more effective than placebo for TD.4
How It Works
How to Use It
DMAE supplementation is not recommended at this time.
Where to Find It
DMAE is found as a supplement, although it is not widely available.
No deficiencies of DMAE are reported or believed to occur.
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
Clinical studies of DMAE have used up to 1,600 mg per day with no reports of side effects.5 For this reason, DMAE is believed to be relatively nontoxic. However, one study using higher intakes for Alzheimer’s disease patients did report symptoms of drowsiness and confusion with the use of DMAE.6 A possible side effect of lucid dreaming (in which the dreamer is conscious and in control of a dream) is suggested with DMAE use.7 Depression and hypomania (moderate symptoms of mania) have been reported as side effects of DMAE.8
1. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia. Treatment with Deanol. J Am Geriatr Soc 1977;25:241-4.
2. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2.
3. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia. N Engl J Med 1974;291:797 [letter].
4. Soares, KV, McGrath JJ. The treatment of tardive dyskinesia-a systematic review and meta-analysis. Schizophr Res 1999;39:1-16 [review].
5. Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia. N Engl J Med 1974;291:797 [letter].
6. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2.
7. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7.
8. Casey DE. Mood alterations during deanol therapy. Psychopharmacology 1979;62:187-91.
Last Review: 06-01-2015
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