TrazodoneSkip to the navigation
Trazodone is a weak serotonin reuptake inhibitor drug with other effects on brain neurotransmitters. It is used to treat people with depression. It is also used to treat people during cocaine withdrawal.
Common brand names:Desyrel
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Potential Negative Interaction
Digitalis (Digitalis lanata, Digitalis purpurea) refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin.
Trazodone was associated with increased serum digoxin levels in one case report.1 No interactions between trazodone and digitalis have been reported. Until more is known, trazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
There is one case report of an elderly patient with Alzheimer’s disease going into a coma while concurrently using trazodone and ginkgo.2 Until more is known, ginkgo should not be combined with trazodone except under supervision of a doctor.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
St. John’s Wort
One report described a case of serotonin syndrome in a patient who took St. John’s wort and trazodone.3 The patient reportedly experienced mental confusion, muscle twitching, sweating, flushing, and ataxia. Until more is known, St. John’s wort should not be combined with trazodone except under expert clinical supervision.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
1. Rauch PK, Jenike MA. Digoxin toxicity possibly precipitated by trazodone. Psychosomatics 1984;25:334-5.
2. Galluzzi S, Zanetti O, Binetti G, et al. Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba. J Neurol Neurosurg Psychiatry 2000;68:679-80.
3. Demott K. St. John's wort tied to serotonin syndrome. Clinical Psychiatry News 1998;26:28.
Last Review: 03-18-2015
Copyright © 2015 Aisle7. All rights reserved. Aisle7.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.
PeaceHealth endeavors to provide comprehensive health care information, however some topics in this database describe services and procedures not offered by our providers or within our facilities because they do not comply with, nor are they condoned by, the ethics policies of our organization.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.