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Timolol is a beta-blocker drug used to lower blood pressure in people with hypertension, treat people after heart attacks, and prevent migraine headaches. Timolol is available alone and in a combination product used to lower blood pressure. Timolol is also available in eye drop and eye gel preparations used to lower high internal eye pressure due to glaucoma and other conditions.
Common brand names:Betimol, Istalol, Timoptic XE
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
In a group of 16 glaucoma patients treated with a timolol eye preparation, six weeks of oral coenzyme Q10 (90 mg per day) was reported to reduce timolol-induced cardiovascular side effects without affecting intraocular pressure treatment.1
Potential Negative Interaction
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.2The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Some beta-adrenergic blockers (called “nonselective” beta blockers) decrease the uptake of potassium from the blood into the cells,3 leading to excess potassium in the blood, a potentially dangerous condition known as hyperkalemia.4 People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their doctor.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
1. Takahashi N, Iwasaka T, Sugiura T, et al. Effect of coenzyme Q10 on hemodynamic response to ocular timolol. J Cardiovasc Pharmacol 1989;14:462-8.
2. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213-4.
3. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 1980;302:431-4.
4. Lundborg P. The effect of adrenergic blockade on potassium concentrations in different conditions. Acta Med Scand Suppl 1983;672:121-6 [review].
Last Review: 03-18-2015
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