QuinidineSkip to the navigation
Quinidine is used to treat and prevent certain forms of heart arrhythmia.
Common brand names:Quinidex Extentabs
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Some people taking quinidine develop sensitivity to ultraviolet radiation from the sun. In a preliminary study, three people with quinidine-induced skin inflammation were able to tolerate intense sun exposure without recurrence of the rash after supplementing with 90–180 mg of beta-carotene each day.1 Further research is needed to confirm that people taking quinidine can prevent side effects by supplementing with beta-carotene.
Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.2 , 3 Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.
Potential Negative Interaction
Drinking grapefruit juice together with quinidine increases the amount of time that the drug remains in the body,4 which might increase the likelihood of side effects and toxicity. Therefore, based on currently available information, people taking quinidine should avoid drinking grapefruit juice or eating grapefruit.
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.5 , 6 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with quinidine in the same way that grapefruit juice does.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
One controlled study showed that people consuming a high-salt diet had dramatically lower quinidine blood levels compared with people on a low-salt diet.7 Problems might occur when people switch from a high-salt diet to a low-salt diet and vice versa. Therefore, people taking quinidine should notify their health practitioner before changing their salt intake.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
One controlled study showed that people consuming a high-salt diet had dramatically lower quinidine blood levels compared with people on a low-salt diet.8 Problems might occur when people switch from a high-salt diet to a low-salt diet and vice versa. Therefore, people taking quinidine should notify their health practitioner before changing their salt intake.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
1. Fisher DA. Quinidine photosensitivity. Arch Dermatol 1984;120:298 [letter].
2. Sasse M, Paul T, Bergmann P, Kallfelz HC. Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate. Pacing Clin Electrophysiol 1998;21:1164-6.
3. Arstall MA, Hii JT, Lehman RG, Horowitz JD. Sotalol-induced torsade de pointes: management with magnesium infusion. Postgrad Med J 1992;68:289-90.
4. Damkier P, Hansen LL, Brosen K. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol 1999;48:829-38.
5. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
6. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
7. Darbar D, Dell'Orto S, Morike K, et al. Dietary salt increases first-pass elimination of oral quinidine. Clin Pharmacol Ther 1997;61:292-300.
8. Darbar D, Dell'Orto S, Morike K, et al. Dietary salt increases first-pass elimination of oral quinidine. Clin Pharmacol Ther 1997;61:292-300.
Last Review: 03-18-2015
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