FexofenadineSkip to the navigation
Fexofenadine is a selective antihistamine used to relieve seasonal allergies (allergic rhinitis) symptoms including sneezing, runny nose, itching, and watery eyes. Fexofenadine is available alone and in a combination product.
Common brand names:Allegra, Allegra ODT
Summary of Interactions with Vitamins, Herbs, & Foods
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Potential Negative Interaction
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.1 , 2 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with fexofenadine in the same way that grapefruit juice does.
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.3 , 4 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with fexofenadine in the same way that grapefruit juice does.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
St. John’s Wort
In a study of healthy volunteers, administration of 900 mg of St. John's wort one hour prior to fexofenadine resulted in a significant increase in blood levels of fexofenadine, compared with the blood levels after taking fexofenadine alone.5 On the other hand, long-term administration of St. John's wort (300 mg three times per day for two weeks) did not alter blood levels of fexofenadine. Until more is known, St. John's wort should not be combined with fexofenadine, except under the supervision of a doctor.
1. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
2. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
3. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6.
4. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472-3.
5. Wang Z, Hamman MA, Huang SM, et al. Effect of St John's wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther2002;71:414-20.
Last Review: 03-18-2015
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