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Doxylamine is an antihistamine used for short-term treatment of insomnia. Doxylamine is available alone in a nonprescription product for sleep and in combination with nonprescription drugs to treat symptoms of allergy, colds, and upper respiratory infections.
Common brand names:Aldex AN, Unisom Nighttime Sleep-Aid
Summary of Interactions with Vitamins, Herbs, & Foods
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Potential Negative Interaction
Antihistamines, including doxylamine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane (Hyoscyamus niger) also has anticholinergic activity and side effects. Therefore, use with doxylamine could increase the risk of anticholinergic side effects;1 however, apparently no interactions have yet been reported with doxylamine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Last Review: 03-18-2015
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