Drug Information

Celecoxib is used to treat rheumatoid arthritis and osteoarthritis; it is in a class of medications known as selective COX-2 inhibitor non-steroidal anti-inflammatory drugs (NSAIDs).

Common brand names:

Celebrex

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • Iron

    NSAIDs cause gastrointestinal (GI) irritation, bleeding, and iron loss. Iron supplements can cause GI irritation. However, iron supplementation is sometimes needed in people taking NSAIDs if those drugs have caused enough blood loss to lead to iron deficiency. If both iron and nabumetone are prescribed, they should be taken with food to reduce GI irritation and bleeding risk.

Reduce Side Effects

  • Licorice

    The flavonoids found in the extract of licorice (Glycyrrhiza glabra) known as DGL (deglycyrrhizinated licorice) are helpful for avoiding the irritating actions NSAIDs have on the stomach and intestines. One study found that 350 mg of chewable DGL taken together with each dose of aspirin reduced gastrointestinal bleeding caused by the aspirin. DGL has been shown in controlled human research to be as effective as drug therapy (cimetidine) in healing stomach ulcers.

Support Medicine

  • Stinging Nettle

    In a controlled human study, people who took stinging nettle with diclofenac obtained similar pain relief compared to people taking twice as much diclofenac with no stinging nettle. More research is needed to determine whether people taking diclofenac might benefit from also taking stinging nettle.

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Sodium

    Controlled studies indicate that individuals on low-salt diets who take celecoxib retain sodium and potassium, which might result in higher than normal blood levels of these minerals. More research is needed to determine whether potassium supplements might produce unwanted side effects in people taking celecoxib. Until more information is available, people taking celecoxib should have their sodium and potassium blood levels monitored by their healthcare practitioner.

  • White Willow

    Willow bark (Salix alba) contains salicin, which is related to aspirin. Both salicin and aspirin produce anti-inflammatory effects after they have been converted to salicylic acid in the body. Taking aspirin and celecoxib together increases the likelihood of developing stomach and intestinal ulcers. Though no studies have investigated a similar interaction between willow bark and celecoxib, people taking the drug should avoid the herb until more information is available.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Explanation Required 

  • Potassium

    Controlled studies indicate that individuals on low-salt diets who take celecoxib retain sodium and potassium, which might result in higher than normal blood levels of these minerals. More research is needed to determine whether potassium supplements might produce unwanted side effects in people taking celecoxib. Until more information is available, people taking celecoxib should have their sodium and potassium blood levels monitored by their healthcare practitioner.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.