AlendronateSkip to the navigation
Alendronate is a member of the bisphosphonate family of drugs used to treat/prevent osteoporosis. It is also used to treat some bone diseases and some cases of cancer that have spread to bones.
Common brand names:Fosamax
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Potential Negative Interaction
Calcium supplements may interfere with alendronate absorption.1 However, one researcher suggested that addition of large amounts of supplemental calcium to alendronate therapy in patients with bone metastases (with evidence of osteomalacia) related to prostate cancer might improve the clinical outcome.2 Moreover, both calcium and alendronate are commonly used in the treatment of osteoporosis in the same people. To prevent potential interactions, alendronate should be taken two hours before or after calcium supplements.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Absorption of tiludronate, a drug related to alendronate, is reduced when taken with magnesium and/or aluminum-containing antacids.3 This interaction has not yet been reported with alendronate. Until more is known, alendronate should be taken two hours before or after magnesium and/or aluminum-containing antacids.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
1. Threlkeld DS, ed. Hormones, Bisphosphonates. InFacts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1998, 134r.
2. Adami S. Bisphosphonates in prostate carcinoma. Cancer 1997;80:1674-9.
3. Threlkeld DS, ed. Hormones, Bisphosphonates. InFacts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Jul 1998, 134r.
Last Review: 03-18-2015
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