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Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Musculoskeletal pain is one of the side effects of zoledronic acid. In a double-blind trial, supplementation with a single dose of vitamin D (300,000 IU) significantly decreased the severity of musculoskeletal pain in women being treated with zoledronic acid.1 The large amount of vitamin D used in this study has the potential to cause adverse effects, and therefore should be taken only under medical supervision.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Potential Negative Interaction
1. Catalano A, Morabito N, Atteritano M, et al. Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis. Calcif Tissue Int 2012;90:279-85.
2. Catalano A, Morabito N, Atteritano M, et al. Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis. Calcif Tissue Int 2012;90:279-85.
3. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.
4. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.
Last Review: 03-24-2015
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