Zoledronic Acid-Mannitol&Water

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Drug Information

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • Vitamin D
    Musculoskeletal pain is one of the side effects of zoledronic acid. In a double-blind trial, supplementation with a single dose of vitamin D (300,000 IU) significantly decreased the severity of musculoskeletal pain in women being treated with zoledronic acid.1 The large amount of vitamin D used in this study has the potential to cause adverse effects, and therefore should be taken only under medical supervision.
    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Support Medicine

  • none

Reduces Effectiveness

  • Iron

    Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed.3 Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.

  • Zinc

    Taking risedronate at the same time as iron, zinc, or magnesium may reduce the amount of drug absorbed.4 Therefore, people taking risedronate who wish to supplement with these minerals should take them an hour before or two hours after the drug.

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Catalano A, Morabito N, Atteritano M, et al. Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis. Calcif Tissue Int 2012;90:279-85.

2. Catalano A, Morabito N, Atteritano M, et al. Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis. Calcif Tissue Int 2012;90:279-85.

3. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.

4. Sifton DW, ed. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2504-6.