Drug Information

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • Vitamin E
    One of the side effects of sorafenib is a severe skin reaction (hand-foot skin syndrome) that often ends treatment. In a preliminary study, supplementing with 300 IU per day of vitamin E produced marked improvement in sorafenib-induced hand-foot skin syndrome within 10 to 12 days, even though the patients continued to take the sorafenib.1
    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • none

Explanation Required 

  • none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.


1. Bozkurt Duman B, Kara B, Oguz Kara I, et al. Hand-foot syndrome due to sorafenib in hepatocellular carcinoma treated with vitamin E without dose modification; a preliminary clinical study. J BUON 2011;16:759-64.