Chlorphen-Phenyltolox-PE-PPA

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Drug Information

Summary of Interactions with Vitamins, Herbs, & Foods

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

  • none

Reduce Side Effects

  • none

Support Medicine

  • none

Reduces Effectiveness

  • none

Potential Negative Interaction

  • Ephedra

    Ephedra is the plant from which the drug ephedrine was originally isolated. Phenylpropanolamine and ephedrine have similar effects and side effects.1 Until 2004, ephedra, also called ma huang, was used in many herbal products including supplements promoted for weight loss.

    While interactions between phenylpropanolamine and ephedra have not been reported, it seems likely that such interactions could occur. To prevent potential problems, people taking phenylpropanolamine-containing products should avoid using ephedra/ephedrine-containing products.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Explanation Required 

  • Fo-Ti

    Many drugs used in the treatment of high blood pressure cause relaxation or dilation of blood vessels. Laboratory studies show that emodin, a compound in Polygonum multiflorum, also relaxes blood vessels. However, animal studies reveal that phenylephrine blocks the action of emodin.5 Controlled studies are needed to determine whether Polygonum multiflorum helps people with high blood pressure and whether phenylephrine blocks its beneficial effects.

    The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Threlkeld DS, ed. Respiratory Drugs, Sympathomimetics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1994, 173a-3h.

2. Threlkeld DS, ed. Respiratory Drugs, Sympathomimetics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1994, 173a-3h.

3. Threlkeld DS, ed. Respiratory Drugs, Sympathomimetics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1994, 173a-3h.

4. Threlkeld DS, ed. Respiratory Drugs, Sympathomimetics. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1994, 173a-3h.

5. Huang HC, Lee CR, Chao PD, et al. Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb. Eur J Pharmacol 1991;205:289-94.