Peyronie's disease is an abnormal curvature of the penis caused by scar tissue in the erectile tissue. Because the scar tissue prevents straightening of the penis, the curvature is most obvious during an erection. The curvature may be so severe that it prevents penetration during intercourse.
Peyronie's disease usually affects men who are 50 and older.
Although the exact cause of Peyronie's disease is unknown, some experts believe the scarring is caused by injury to the penis (such as being bent or hit).
Peyronie's disease is not caused by cancer and does not increase the risk of cancer. It is not caused by sexually transmitted infections (STIs).
Symptoms of Peyronie's disease may develop slowly or suddenly. Common symptoms include:
Peyronie's disease is usually divided into two stages:
Peyronie's disease is usually diagnosed using a medical history and physical exam. Your doctor will ask you questions about when you first noticed your symptoms and whether the symptoms were gradual or sudden. This will help determine which stage of Peyronie's disease you are experiencing.
Because symptoms of Peyronie's disease are usually most noticeable when the penis is erect, your doctor may ask you to take a photograph of your penis while it is erect. Other tests that may be ordered include:
Peyronie's disease rarely gets better on its own. But treatment usually is not needed unless Peyronie's disease causes pain or interferes with sexual function.
Most men are able to remain sexually active. Counseling can help couples maintain an active sexual life.
Although there is no standard treatment for Peyronie's disease, vitamin E or medicines such as carnitine, colchicine, or verapamil may help treat pain and reduce curvature during an erection. But the use of medicines has shown only limited success, and none are well studied for the treatment of Peyronie's disease.1
Surgery is considered for men who have severe pain, a severely curved penis, or sexual dysfunction related to Peyronie's disease. Surgical options include removing the scar tissue or shortening the unaffected side of the penis (plication). In some cases, use of a penile prosthesis may be used to help keep an erection during intercourse.
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- Jordan GH, McCammon KA (2012). Peyronie's disease. In AJ Wein et al., eds., Campbell-Walsh Urology, 10th ed., vol. 1, pp. 792–809. Philadelphia: Saunders.
Other Works Consulted
- McAninch JW (2008). Disorders of the penis and male urethra. In EA Tanagho, JW McAninch, eds., Smith's General Urology, 17th ed., pp. 625–637. New York: McGraw-Hill Medical.
|Primary Medical Reviewer||E. Gregory Thompson, MD - Internal Medicine|
|Specialist Medical Reviewer||Christopher G. Wood, MD, FACS - Urology, Oncology|
|Last Revised||September 7, 2012|
Last Revised: September 7, 2012
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