Together, this group of health problems increases your risk of heart attack, stroke, and diabetes.
Metabolic syndrome is caused by an unhealthy lifestyle that includes eating too many calories, being inactive, and gaining weight, particularly around your waist. This lifestyle can lead to insulin resistance, a condition in which the body is unable to respond normally to insulin. If you have insulin resistance, your body cannot use insulin properly, and your blood sugar will begin to rise. Over time, this can lead to type 2 diabetes.
If you have metabolic syndrome, you have several disorders of the metabolism at the same time, including obesity (usually around your waist), high blood pressure, low HDL cholesterol, and resistance to insulin.
The things that make you more likely to develop metabolic syndrome include:1
Your doctor can diagnose metabolic syndrome with a physical exam, your medical history, and some simple blood tests.
You may be diagnosed with metabolic syndrome if you have three or more of the risk factors listed in the table below. Note: These criteria were developed by the National Heart, Lung, and Blood Institute. Other organizations may have different criteria for diagnosis.
Abdominal obesity (waist measurement)
Men: 40 in. (102 cm) or more
Women: 35 in. (88 cm) or more
150 mg/dL or higher, or taking medicine for high triglycerides
High-density lipoprotein (HDL) cholesterol
Men: Less than 40 mg/dL
Women: Less than 50 mg/dL
Or taking medicine for low HDL cholesterol
130/85 mm Hg or higher, or taking medicine for high blood pressure
Fasting blood sugar
100 mg/dL or higher, or taking medicine for high blood sugar
The main goal of treatment is to reduce your risk of coronary artery disease (CAD) and diabetes. The first approaches in treating metabolic syndrome are:
|American Diabetes Association (ADA)|
|1701 North Beauregard Street|
|Alexandria, VA 22311|
The American Diabetes Association (ADA) is a national organization for health professionals and consumers. Almost every state has a local office. ADA sets the standards for the care of people with diabetes. Its focus is on research for the prevention and treatment of all types of diabetes. ADA provides patient and professional education mainly through its publications, which include the monthly magazine Diabetes Forecast, books, brochures, cookbooks and meal planning guides, and pamphlets. ADA also provides information for parents about caring for a child with diabetes.
|American Heart Association (AHA)|
|7272 Greenville Avenue|
|Dallas, TX 75231|
Visit the American Heart Association (AHA) website for information on physical activity, diet, and various heart-related conditions. You can search for information on heart disease and stroke, share information with friends and family, and use tools to help you make heart-healthy goals and plans. Contact the AHA to find your nearest local or state AHA group. The AHA provides brochures and information about support groups and community programs, including Mended Hearts, a nationwide organization whose members visit people with heart problems and provide information and support.
|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|
|Building 31, Room 9A06|
|31 Center Drive, MSC 2560|
|Bethesda, MD 20892-2560|
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) provides information and conducts research on a wide variety of diseases as well as issues such as weight control and nutrition.
- Grundy SM, et al. (2005). Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 112(17): 2735–2752.
Other Works Consulted
- Alberti K, et al. (2009). Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force of Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation, 120(16): 1640–1645.
- Brownlee M, et al. (2011). Complications of diabetes mellitus. In S Melmed et al., eds., Williams Textbook of Endocrinology, 12th ed., pp. 1462–1551. Philadelphia: Saunders.
- Brunzell JD (2010). Diagnosis and treatment of dyslipidemia. In EG Nabel, ed., ACP Medicine, section 9, chap. 6. Hamilton, ON: BC Decker.
- Eckel RH (2012). The metabolic sydrome. In DL Longo et al., eds., Harrison's Principals of Internal Medicine, 18th ed., vol. 2, pp. 1992–1997. New York: McGraw-Hill.
- Hawkins M, Rossetti L (2005). Insulin resistance and its role in the pathogenesis of type 2 diabetes. In Joslin's Diabetes Mellitus, 14th ed., pp. 425–448. Philadelphia: Lippincott Williams and Wilkins.
- Masharani U, German MS (2011). Pancreatic hormones and diabetes mellitus. In DG Gardner, D Shoback, eds., Greenspan's Basic and Clinical Endocrinology, 9th ed., pp. 573–655. New York: McGraw-Hill.
|Primary Medical Reviewer||E. Gregory Thompson, MD - Internal Medicine|
|Specialist Medical Reviewer||Jennifer Hone, MD - Endocrinology, Diabetes and Metabolism|
|Last Revised||May 22, 2012|
Last Revised: May 22, 2012
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