Some people who have hemophilia A develop antibodies to the injected clotting factor. The body thinks that the replacement clotting factors don't belong in the body, so it creates the antibodies, also called inhibitors, to get rid of them.
Inhibitors may make it harder to treat bleeding episodes because the body's natural defense system (immune system) interferes with the function of replacement clotting factors.
Some people produce few inhibitors; others produce many.
If you have inhibitors, hemophilia treatment may require specially engineered replacement clotting factors. Other treatment for clotting factor inhibitors includes therapy to suppress the immune system (immunosuppressive therapy).
If you have a larger amount of inhibitors, you might be treated with:
If your body produces few inhibitors in reaction to clotting factors, you may be treated with clotting factor concentrate that is made in a lab (recombinant clotting factors). You might get large doses of the clotting factors, which can overwhelm the inhibitors.
Other Works Consulted
- Roberts HR, et al. (2010). Hemophilia A and hemophilia B. In K Kaushansky et al., eds., Williams Hematology, 8th ed., pp. 2009–2029. New York: McGraw-Hill.
|Primary Medical Reviewer||E. Gregory Thompson, MD - Internal Medicine|
|Specialist Medical Reviewer||Brian Leber, MDCM, FRCPC - Hematology|
|Last Revised||August 3, 2011|
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