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Paget's Disease of the Breast

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Paget's Disease of the Breast is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • mammary Paget's disease
  • Paget's disease of the nipple
  • Paget's disease of the nipple and areola

Disorder Subdivisions

  • None

General Discussion

Summary
Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been reported in men. Paget's disease of the breast is characterized by inflammatory, "eczema-like" changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In individuals with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple, when viewed under a microscope. Most women with this disorder have an underlying cancer (malignancy) affecting the milk ducts (ductal carcinoma). The milk ducts are the channels that carry milk secreted by lobes of the breast to the nipple. The exact cause of Paget's disease of the breast is not fully understood.

Introduction
Paget's disease of the breast was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct entities that are medically unrelated.

Resources

National Women's Health Network
1413 K Street, NW
4th Floor
Washington, DC 20005
USA
Tel: (202)682-2640
Fax: (202)682-2648
Email: nwhn@nwhn.org
Internet: http://www.womenshealthnetwork.org

Skin Cancer Foundation
149 Madison Avenue
Suite 901
New York, NY 10016
Tel: (212)725-5176
Fax: (212)725-5751
Tel: (800)754-6490
Email: info@skincancer.org
Internet: http://www.skincancer.org

American Cancer Society, Inc.
250 Williams NW St
Ste 6000
Atlanta, GA 30303
USA
Tel: (404)320-3333
Tel: (800)227-2345
TDD: (866)228-4327
Internet: http://www.cancer.org

Rose Kushner 's Women's Breast Cancer Advisory Center
P.O. Box 757
Malaga Cove, CA 90274
Email: lkkushner@yahoo.com
Internet: http://www.rkbcac.org/

National Cancer Institute Physician Data Query
Office of Communications and Education
Public Inquiries Office
6116 Executive Blvd
Suite 300
Bethesda, MD 20892-8322
Tel: (800)422-6237
Email: cancergovstaff@mail.nih.gov
Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase

National Cancer Institute
6116 Executive Blvd Suite 300
Bethesda, MD 20892-8322
USA
Tel: (301)435-3848
Tel: (800)422-6237
TDD: (800)332-8615
Email: cancergovstaff@mail.nih.gov
Internet: http://www.cancer.gov

OncoLink: The University of Pennsylvania Cancer Center Resource
3400 Spruce Street
2 Donner
Philadelphia, PA 19104-4283
USA
Tel: (215)349-8895
Fax: (215)349-5445
Email: hampshire@uphs.upenn.edu
Internet: http://www.oncolink.upenn.edu

SHARE - Self-Help For Women With Breast or Ovarian Cancer
1501 Broadway
Suite 704A
New York, NY 10036
Tel: (212)719-0364
Fax: (212)869-3431
Tel: (866)891-2392
Email: info@sharecancersupport.org
Internet: http://www.sharecancersupport.org/

Canadian Breast Cancer Network
331 Cooper Street, Suite 300
Ottawa
Ontario, K2P 0G5
Canada
Tel: 6132303044
Fax: 6132304424
Tel: 8006858820
Email: cbcn@cbcn.ca
Internet: http://www.cbcn.ca

Breast Cancer Society of Canada
420 East Street North
Sarnia
Ontario, N7T 6Y5
Canada
Tel: 5193360746
Fax: 5193365725
Tel: 8005678767
Email: bcsc@bcsc.ca
Internet: http://www.bcsc.ca

Rare Cancer Alliance
1649 North Pacana Way
Green Valley, AZ 85614
USA
Internet: http://www.rare-cancer.org

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

Friends of Cancer Research
1800 M Street NW
Suite 1050 South
Washington, DC 22202
Tel: (202)944-6700
Email: info@focr.org
Internet: http://www.focr.org

Cancer Support Community
1050 17th St NW Suite 500
Washington, DC 20036
Tel: (202)659-9709
Fax: (202)974-7999
Tel: (888)793-9355
Internet: http://www.cancersupportcommunity.org/

Lance Armstrong Foundation
2201 E. Sixth Street
Austin, TX 78702
Tel: (512)236-8820
Fax: (512)236-8482
Tel: (877)236-8820
Email: media@livestrong.org
Internet: http://www.livestrong.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  3/27/2012
Copyright  1990, 2000, 2012 National Organization for Rare Disorders, Inc.

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