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abiraterone

Pronunciation: A bir A te rone

Brand: Zytiga

What is the most important information I should know about abiraterone?

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You should not use this medication if you are allergic to abiraterone, if you have severe liver disease, or if you are pregnant.

Before you take abiraterone, tell your doctor if you have liver disease, low levels of potassium in your blood, any type of infection, high blood pressure, congestive heart failure, or a history of heart disease, fluid retention, recent heart attack, or problems with your adrenal gland or pituitary gland.

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Although abiraterone is not for use by women, this medicine can harm an unborn baby or cause birth defects. Abiraterone tablets should not be handled by a woman who is pregnant or who may become pregnant.

While you are taking abiraterone and for at least 1 week after your treatment ends: Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant. Use a condom plus another form of effective birth control if your sexual partner could become pregnant.

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Abiraterone must be taken on an empty stomach.

What is abiraterone?

Abiraterone works in the body by preventing the actions of androgens (male hormones).

Abiraterone is used together with prednisone to treat prostate cancer that has spread to other parts of the body.

Abiraterone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking abiraterone?

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You should not use this medication if you are allergic to abiraterone, if you have severe liver disease, or if you are pregnant.

To make sure abiraterone is safe for you, tell your doctor if you have:

  • liver disease;
  • heart disease, high blood pressure;
  • low levels of potassium in your blood;
  • a history of heart disease, fluid retention, or recent heart attack; or
  • a history of problems with your adrenal gland or pituitary gland.

While you are taking abiraterone and for at least 1 week after your treatment ends:

  • If your sexual partner is pregnant--Use a condom to prevent transfer of this medication to her.
  • If your sexual partner could become pregnant--Use a condom plus another form of effective birth control to prevent pregnancy.
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FDA pregnancy category X. Although abiraterone is not for use by women, this medication can harm an unborn baby or cause birth defects. Abiraterone tablets should not be handled by a woman who is pregnant or who may become pregnant. If this cannot be avoided, the woman should wear latex gloves.

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It is not known whether abiraterone passes into breast milk or if it could harm a nursing baby. Abiraterone should not be used by a woman who is breast-feeding a baby.

How should I take abiraterone?

Follow all directions on your prescription label. Abiraterone is usually taken once per day while also taking prednisone two times per day. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Your prednisone dosage needs may change if you have surgery, are ill, or are under stress. Do not change your medication dose or schedule without your doctor's advice.

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Take this medicine with a full glass of water. Swallow the abiraterone tablet whole.

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Take abiraterone on an empty stomach. Do not eat anything for at least 2 hours before you take abiraterone and for at least 1 hour after you have taken the medicine.

Your blood pressure will need to be checked often, and you may need frequent blood tests at your doctor's office.

You should not stop using abiraterone or prednisone suddenly. Follow your doctor's instructions about tapering your prednisone dose.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and take the medicine the following day on an empty stomach (no food for at least 2 hours before or 1 hour after you take abiraterone). Do not take extra medicine to make up the missed dose.

Call your doctor for instructions if you miss more than one dose of abiraterone.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking abiraterone?

Avoid eating for at least 2 hours before you take abiraterone and for at least 1 hour after your dose. Food can increase the amount of abiraterone your body absorbs.

What are the possible side effects of abiraterone?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Stop using abiraterone and call your doctor at once if you have:

  • swelling in your ankles or feet, pain in your legs;
  • rapid heartbeats, feeling short of breath (even with mild exertion);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • pale skin, easy bruising, feeling like you might pass out;
  • upper stomach pain, itching, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
  • pain or burning when you urinate;
  • high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
  • worsening dizziness, weakness, or tired feeling;
  • nausea, vomiting, ongoing diarrhea; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Common side effects may include:

  • swelling or discomfort in your joints;
  • mild diarrhea;
  • cough; or
  • sweating, feeling very hot.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect abiraterone?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with abiraterone, especially:

  • cough or cold medicine that contains dextromethorphan;
  • the heart rhythm medicines flecainide or propafenone;
  • prostate or breast cancer medications such as leuprolide, buserelin, histrelin, or goserelin;
  • thioridazine;
  • an antidepressant--amitriptyline, doxepin, clomipramine, desipramine, imipramine, nortriptyline.

This list is not complete. Other drugs may interact with abiraterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about abiraterone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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