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amlodipine, hydrochlorothiazide, and olmesartan

Pronunciation: am LOE di peen, HYE droe KLOR oh THYE a zide, and OL me SAR tan

Brand: Tribenzor

What is the most important information I should know about amlodipine, hydrochlorothiazide, and olmesartan?

Multum nopreg

Do not take this medication if you are pregnant. Stop using the medication and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

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You should not use this medication if you are allergic to amlodipine, hydrochlorothiazide, or olmesartan, or if you have severe kidney disease, if you are unable to urinate, or if you are allergic to sulfa drugs.

Before you take amlodipine, hydrochlorothiazide, and olmesartan, tell your doctor if you have kidney or liver disease, congestive heart failure, angina (chest pain), severe coronary artery disease, glaucoma, lupus, diabetes, a penicillin allergy, if you are dehydrated, or if you are vomiting or having diarrhea.

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You should not breast-feed while you are taking this medication.

Multum calldoc

Call your doctor at once if you have any signs of an electrolyte imbalance, such as: headache, trouble concentrating, memory problems, weakness, feeling unsteady, nausea, loss of appetite, extreme thirst, increased urination, leg discomfort, jerking muscle movements, muscle weakness or limp feeling, shallow breathing, uneven heart rate, confusion, feeling tired or restless, hallucinations, fainting, or seizure.

What is amlodipine, hydrochlorothiazide, and olmesartan?

Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Olmesartan is an angiotensin II receptor antagonist. Olmesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Amlodipine, hydrochlorothiazide, and olmesartan is a combination medicine used to treat high blood pressure (hypertension). This medication is usually given after others have been tried without successful treatment of hypertension.

Amlodipine, hydrochlorothiazide, and olmesartan may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking amlodipine, hydrochlorothiazide, and olmesartan?

Multum donot

You should not use this medication if you are allergic to amlodipine (Norvasc), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic), or olmesartan (Benicar), or if you have:

  • severe kidney disease;
  • if you are unable to urinate; or
  • if you are allergic to sulfa drugs.

If you have diabetes or kidney disease, you may not be able to take amlodipine, hydrochlorothiazide, and olmesartan if you are also taking a blood pressure medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, or Valturna).

To make sure this medicine is safe for you, tell your doctor if you have:

  • kidney disease;
  • liver disease;
  • congestive heart failure;
  • angina (chest pain), severe coronary artery disease;
  • glaucoma;
  • lupus;
  • diabetes;
  • a penicillin allergy;
  • if you are dehydrated; or
  • if you are vomiting or having diarrhea.
Multum nopreg

FDA pregnancy category D. Do not take amlodipine, hydrochlorothiazide, and olmesartan if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking this medication.

Multum nobrfeed

It is not known whether amlodipine, hydrochlorothiazide, and olmesartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking this medication.

How should I take amlodipine, hydrochlorothiazide, and olmesartan?

This medication is usually taken once per day. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Amlodipine, hydrochlorothiazide, and olmesartan may be taken with or without food.

You may have new or worsening chest pain when you first start taking this medicine, or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often.

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amlodipine, hydrochlorothiazide, and olmesartan?

Multum donot

Do not use potassium supplements or salt substitutes while you are taking amlodipine, hydrochlorothiazide, and olmesartan, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

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Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medication.

What are the possible side effects of amlodipine, hydrochlorothiazide, and olmesartan?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have:

  • eye pain, vision problems;
  • a light-headed feeling, like you might pass out;
  • swelling in your hands, ankles, or feet;
  • little or no urinating;
  • pain or burning when you urinate;
  • joint pain or swelling with fever, swollen glands, muscle aches, unusual thoughts or behavior, patchy skin color, red spots, or skin rash on your face;
  • headache, trouble concentrating, memory problems, weakness, feeling unsteady, hallucinations, fainting, seizure, shallow breathing;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
  • electrolyte imbalance--nausea, loss of appetite, uneven heart rate, extreme thirst, increased urination, leg discomfort, jerking muscle movements, muscle weakness or limp feeling, confusion, and feeling tired or restless.

Common side effects may include:

  • dizziness;
  • diarrhea;
  • muscle spasms;
  • cold symptoms such as stuffy nose, sneezing, sore throat; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amlodipine, hydrochlorothiazide, and olmesartan?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with amlodipine, hydrochlorothiazide, and olmesartan, especially:

  • other medications that lower blood pressure;
  • heart medication or another diuretic (water pill);
  • potassium supplements or salt substitutes;
  • cholestyramine or colestipol;
  • insulin or oral diabetes medication;
  • lithium;
  • simvastatin;
  • steroid medication such as prednisone and others;
  • a barbiturate--butabarbital, secobarbital, pentobarbital, phenobarbital;
  • NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
  • narcotic medication such as codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone, and many others.

This list is not complete. Other drugs may interact with amlodipine, hydrochlorothiazide, and olmesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about amlodipine, hydrochlorothiazide, and olmesartan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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