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denileukin diftitox

Pronunciation: de ni LOO kin DIF ti tox

Brand: Ontak

What is the most important information I should know about denileukin diftitox?

Multum donot

You should not use denileukin diftitox if you have ever had an allergic reaction to a diphtheria vaccine or to medicines containing interleukin-2 (IL-2).

Denileukin diftitox is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. This medication must be given slowly, and the IV infusion can take at least 15 minutes to complete.

You may have a reaction from a denileukin diftitox injection within hours or days after receiving the injection. Call your doctor promptly if you have one or more of these symptoms: fever, chills, weakness, muscle or joint pain, nausea, vomiting, or stomach upset.

Some patients receiving denileukin diftitox have had permanent changes in their vision or ability to see colors. Talk with your doctor about your individual risk. Tell your doctor if you have any vision changes during your treatment.

What is denileukin diftitox?

Denileukin diftitox is a designed protein containing toxins that attach themselves to certain types of malignant cells in the body. Denileukin diftitox works by destroying these malignant cells to slow the progression of cancer.

Denileukin diftitox is used to treat leukemia and lymphomas, including cutaneous (of the skin) T-cell lymphoma.

Denileukin diftitox may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before using denileukin diftitox?

Multum donot

You should not use denileukin diftitox if you have ever had an allergic reaction to a diphtheria vaccine or to medicines containing interleukin-2 (IL-2).

If you have heart disease, you may need a dose adjustment or special tests.

Multum nopreg

FDA pregnancy category C. It is not known whether denileukin diftitox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether denileukin diftitox passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Some patients receiving denileukin diftitox have had permanent changes in their vision or ability to see colors. Talk with your doctor about your individual risk. Tell your doctor if you have any vision changes during your treatment.

How should I use denileukin diftitox?

Denileukin diftitox is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. This medication must be given slowly, and the IV infusion can take at least 15 minutes to complete. During this time you will be observed for side effects.

Denileukin diftitox is usually given each day for 5 days, followed by 3 weeks off the medication.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis before and during your treatment. Visit your doctor regularly.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your denileukin diftitox injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause severe nausea or vomiting, fever, chills, and extreme weakness.

What should I avoid while receiving denileukin diftitox?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using denileukin diftitox.

What are the possible side effects of denileukin diftitox?

You may have a reaction from a denileukin diftitox injection within hours or days after receiving the injection. Call your doctor promptly if you have one or more of these symptoms: fever, chills, weakness, muscle or joint pain, nausea, vomiting, or stomach upset.

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • blurred vision, changes in color vision;
  • swelling in your hands, ankles, or feet;
  • easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, cough, flu symptoms;
  • fast heart rate;
  • feeling light-headed, fainting;
  • back pain, trouble breathing, chest pain or tightness;
  • trouble swallowing, tight feeling in your throat; or
  • warmth or redness in your face, neck, or chest.

Less serious side effects may include:

  • headache, dizziness, or nervousness;
  • numbness or tingling;
  • runny or stuffy nose;
  • skin itching or rash;
  • weight gain or loss;
  • mild diarrhea or constipation; or
  • nausea, vomiting, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect denileukin diftitox?

There may be other drugs that can interact with denileukin diftitox. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about denileukin diftitox.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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