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divalproex sodium

Pronunciation: dye val PRO ex

Brand: Depakote, Depakote ER, Depakote Sprinkles

Depakote 125 mg

oval, pink, imprinted with a NT

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Depakote 250 mg

oval, orange, imprinted with aNR, a NR

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Depakote 500 mg

oblong, lavender, imprinted with a NS

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Depakote ER 250 mg

oval, white, imprinted with aHF

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Depakote ER 500 mg

oval, gray, imprinted with aHC

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Depakote Sprinkles 125 mg

capsule, blue/white, imprinted with THIS END UP, DEPAKOTE SPRINKLE 125 mg

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Divalproex 500 mg-APO

oblong, white, imprinted with APO 048, 500

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Divalproex Sodium Delayed-Release 125 mg-TEV

oval, brown, imprinted with 93 7439

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Divalproex Sodium Delayed-Release 250 mg-TEV

oval, brown, imprinted with 93 7440

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Divalproex Sodium Delayed-Release 500 mg-TEV

oval, pink, imprinted with 93 7441

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What is the most important information I should know about divalproex sodium?

Multum donot

Divalproex sodium may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant while taking divalproex sodium for seizures. Do not start or stop taking divalproex sodium during pregnancy without your doctor's advice.

Multum emt

Seek emergency medical attention if the person taking this medicine has nausea, vomiting, upper stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage or pancreatitis.

Multum emt

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

What is divalproex sodium?

Divalproex sodium affects chemicals in the body that may be involved in causing seizures.

Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications.

Divalproex sodium may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking divalproex sodium?

Multum emt

In rare cases, divalproex sodium has caused life-threatening liver failure, especially in children younger than 2 years old. Children of this age may be at even greater risk for liver problems if they use more than one seizure medication, if they have a metabolic disorder, or if they have a brain disease causing mental impairment (such as Creutzfeldt-Jacob disease, Huntington disease, multiple sclerosis, or a brain injury or infection).

Multum emt

Divalproex sodium has also caused rare cases of life-threatening pancreatitis (inflammation of the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have been taking divalproex sodium for several years.

Multum donot

You should not take this medication if you are allergic to divalproex sodium, or if you have liver disease or a urea cycle disorder.

To make sure you can safely take divalproex sodium, tell your doctor if you have any of these other conditions:

  • liver disease;
  • a bleeding or blood clotting disorder;
  • a history of head injury, brain disorder, or coma;
  • a family history of a urea cycle disorder or infant deaths with unknown cause; or
  • HIV or CMV (cytomegalovirus) infection.

You may have thoughts about suicide while taking this medication. Tell your doctor if you have new or worsening depression or suicidal thoughts during the first several months of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits. Do not miss any scheduled appointments.

Multum nopreg

FDA pregnancy category D. Divalproex sodium can cause birth defects. Do not start taking divalproex sodium without telling your doctor if you are pregnant or planning to become pregnant. Use effective birth control while you are taking divalproex sodium.

Divalproex sodium may also affect cognitive development in children born to mothers who take this medication during pregnancy. Studies have shown that these children may score lower on cognitive tests (reasoning, intelligence, and problem-solving) than children whose mothers took other seizure medications during pregnancy.

Multum emt

Although divalproex sodium may harm an unborn baby, having a seizure during pregnancy could harm both mother and baby. If you become pregnant while taking divalproex sodium, do not stop taking the medicine without your doctor's advice.

Seizure control is very important during pregnancy. The benefit of preventing seizures may outweigh any risks posed by taking divalproex sodium. There may be other seizure medications that can be more safely used during pregnancy. Follow your doctor's instructions about taking divalproex sodium while you are pregnant.

Multum nobrfeed

Divalproex sodium can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take divalproex sodium?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum water

Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day.

You may open the divalproex sodium sprinkle capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away.

Multum nocrush

Do not crush, chew, break, or open a delayed-release or extended-release tablet or capsule. Swallow it whole.

To be sure this medication is not causing harmful effects, your liver function will need to be tested. Visit your doctor regularly.

Multum donot

Do not stop using divalproex sodium without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using divalproex sodium suddenly. You may need to use less and less before you stop the medication completely.

Multum emt

Wear a medical alert tag or carry an ID card stating that you take divalproex sodium. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking a seizure medication.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include sleepiness or drowsiness, shallow breathing, weak pulse, or loss of consciousness.

What should I avoid while taking divalproex sodium?

Multum noalcohol

Drinking alcohol can increase certain side effects of divalproex sodium.

Multum dizzy

Divalproex sodium may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum nosun

Avoid exposure to sunlight or tanning beds. Divalproex sodium can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of divalproex sodium?

Multum emt

Seek emergency medical attention if the person taking this medicine has nausea, vomiting, upper stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage or pancreatitis.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have any of these other serious side effects:

  • unexplained weakness with vomiting and confusion or fainting;
  • easy bruising or bleeding, blood in your urine;
  • fever, chills, body aches, swollen glands, flu symptoms;
  • urinating less than usual;
  • extreme drowsiness, lack of coordination, hallucinations;
  • double vision or back-and-forth movements of the eyes; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild drowsiness or weakness;
  • diarrhea, constipation, upset stomach;
  • changes in your menstrual periods;
  • enlarged breasts, weight changes;
  • tremor (shaking);
  • hair loss;
  • vision changes; or
  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect divalproex sodium?

Multum dizzy

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to sleepiness caused by divalproex sodium. Tell your doctor if you regularly use any of these medicines, or any other seizure medication.

Tell your doctor about all other medications you use, especially:

  • topiramate (Topamax);
  • tolbutamide (Orinase);
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • aspirin or acetaminophen (Tylenol);
  • zidovudine (Retrovir);
  • clozapine (Clozaril, FazaClo);
  • diazepam (Valium);
  • meropenem (Merrem) or imipenem and cilastatin (Primaxin);
  • rifampin (Rifadin, Rimactane, Rifater); or
  • ethosuximide (Zarontin).

This list is not complete and other drugs may interact with divalproex sodium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about divalproex sodium.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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