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dantrolene (oral)

Pronunciation: DAN troe leen

Brand: Dantrium

Dantrium 25 mg

orange/peach, imprinted with DANTRIUM 25 mg, 0149 0030

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Dantrolene 100 mg-GLO

capsule, red/yellow, imprinted with G443

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Dantrolene 25 mg-GLO

capsule, green/yellow, imprinted with G441

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Dantrolene 50 mg-GLO

capsule, blue/yellow, imprinted with G442

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What is the most important information I should know about dantrolene?

You should not take this medication if you are allergic to dantrolene, or if you have liver disease such as hepatitis or cirrhosis.

Multum emt

You may be more likely to develop liver problems while taking dantrolene if you are a woman, or if you are older than 35. Talk with your doctor about your individual risk.

Multum donot

Do not use dantrolene at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Before taking dantrolene, tell your doctor if you have a history of liver disease, a breathing disorder such as COPD, heart disease, or a history of heart attack.

Multum dizzy

Dantrolene can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Multum emt

Dantrolene can cause muscle weakness, which can affect your ability to swallow. Use caution to prevent choking while you are eating meals. Talk with your doctor if you are unable to eat because of this side effect.

Multum noalcohol

Avoid drinking alcohol. It can increase some of the side effects of dantrolene.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

What is dantrolene?

Dantrolene is a muscle relaxant.

Dantrolene is used to treat muscle spasticity (stiffness and spasms) caused by conditions such as a spinal cord injury, stroke, cerebral palsy, or multiple sclerosis.

Dantrolene is also used to prevent muscle stiffness and spasms caused by malignant hyperthermia (a rapid rise in body temperature) that can occur during surgery with certain types of anesthesia.

Dantrolene may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dantrolene?

You should not take this medication if you are allergic to dantrolene, or if you have liver disease such as hepatitis or cirrhosis.

Multum emt

You may be more likely to develop liver problems while taking dantrolene if you are a woman, or if you are older than 35. Talk with your doctor about your individual risk.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • a history of liver disease;
  • a breathing disorder such as COPD (chronic obstructive pulmonary disease); or
  • heart disease, or a history of heart attack.
Multum nopreg

FDA pregnancy category C. It is not known whether dantrolene is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

Multum nobrfeed

Dantrolene can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Dantrolene should not be given to a child younger than 5 years old.

How should I take dantrolene?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Multum water

Take this medicine with a full glass of water. If you take dantrolene within 4 hours before surgery, use only enough water needed to swallow the pill.

Multum emt

Dantrolene can cause muscle weakness, which can affect your ability to swallow. Use caution to prevent choking while you are eating meals. Talk with your doctor if you are unable to eat because of this side effect.

Multum rt

Store dantrolene at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include vomiting, diarrhea, and extreme drowsiness or muscle weakness.

What should I avoid while taking dantrolene?

Multum donot

Do not use dantrolene at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Multum dizzy

Dantrolene can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Multum noalcohol

Avoid drinking alcohol. It can increase some of the side effects of dantrolene.

Multum nosun

Avoid exposure to sunlight, sunlamps, or tanning beds. Dantrolene can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

What are the possible side effects of dantrolene?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • severe diarrhea or constipation;
  • weak or shallow breathing;
  • pale skin, easy bruising or bleeding;
  • trouble swallowing, especially if it causes choking;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • seizure (black-out or convulsions); or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, dizziness, weakness, tired feeling;
  • mild diarrhea or constipation;
  • mild nausea, vomiting, stomach pain;
  • problems with speech, balance, or walking;
  • headache, confusion, vision problems;
  • sleep problems (insomnia);
  • sweating, drooling; or
  • urinating more than usual.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dantrolene?

Multum dizzy

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, and medicine for seizures, depression or anxiety can add to sleepiness caused by dantrolene. Tell your doctor if you regularly use any of these medicines, or any other muscle relaxers.

Tell your doctor about all other medications you use, especially:

  • birth control pills and other hormones; or
  • a heart or blood pressure medication such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan).

This list is not complete and there may be other drugs that can interact with dantrolene. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about dantrolene.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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