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Indomethacin is sometimes used as a tocolytic medicine to prolong pregnancy by slowing preterm uterine contractions.
Indomethacin is given through a vein (intravenously), by mouth as capsules or liquid (orally), or in the rectum (anal suppository).
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that blocks the production of certain substances called prostaglandins, which contribute to uterine contractions.
Indomethacin is used only:
Indomethacin can be used to treat preterm labor when:
Indomethacin can be effective in delaying preterm labor.1 More research is needed before its harms and benefits are fully known.
Indomethacin appears to have fewer side effects on the mother but potentially more serious effects on the fetus than other tocolytic medicines used to treat preterm labor. But fetal side effects are very unlikely when treatment lasts less than 7 days. Indomethacin may cause:
Maternal side effects are very rare. They include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
Last Revised: January 8, 2013
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