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Cyclobenzaprine is a drug used to relax muscles. Experts do not know exactly how this drug works to improve fibromyalgia. Cyclobenzaprine is chemically similar to amitriptyline, a tricyclic antidepressant. So experts believe that the two drugs may work in similar ways.1
Doctors may prescribe cyclobenzaprine to treat the pain, stiffness, and sleep problems that occur with fibromyalgia.
Side effects include:
Less common side effects include fatigue, weakness, nausea, constipation, stomach upset, blurred vision, nervousness, and confusion.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
It is difficult to measure improvements in painful diseases like fibromyalgia. This makes it hard to tell how effective a drug is in treating this condition.
- Goldenberg DL, et al. (2004). Management of fibromyalgia syndrome. JAMA, 292(19): 2388–2395.
- Tofferi JK, et al. (2004). Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. Arthritis and Rheumatism, 51(1): 9–13.
- Bradley LA, Alarcon GS (2005). Fibromyalgia section of Miscellaneous rheumatic diseases. In WJ Koopman, LW Moreland, eds., Arthritis and Allied Conditions: A Textbook of Rheumatology, 15th ed., vol. 2, pp. 1869–1910. Philadelphia: Lippincott Williams and Wilkins.
Last Revised: October 20, 2011
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