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Triptans narrow (constrict) blood vessels in the brain and relieve swelling. Triptans have other properties that may help treat migraine symptoms. It is not clear how they work to stop a migraine.
All of these drugs are available as tablets. Some tablets are designed to dissolve in your mouth. Sumatriptan is also available as an injection. Both sumatriptan and zolmitriptan are available as a nasal spray.
These drugs are used to effectively and quickly relieve headache pain, sensitivity to light and noise, and nausea and vomiting associated with migraines. They are especially helpful if you have moderate to severe headaches that interfere with your ability to perform daily tasks.
These drugs are effective in reducing migraine symptoms and are well tolerated.1 But it is hard to know which triptan is the most effective. A triptan that works well for someone else may not work well for you. You may have to try more than one triptan to find the one that works best for you.
Triptans work best when they are taken as soon as the headache starts. But they can still reduce headache pain and other symptoms when taken after the attack has begun.
You may find that combining a triptan with a nonprescription medicine (such as acetaminophen or naproxen) helps to stop your headaches better. Talk to your doctor about this option if triptans alone aren't helping enough.
Some triptan drugs may also help to prevent migraines in women who get them only around the time of their menstrual period. A study suggested that these women may be able to prevent the headache by taking frovatriptan (Frova) for 6 days, starting treatment 2 days before their period begins.2 Frovatriptan is a triptan drug that is commonly used to relieve migraine pain after the headache has started.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call 911 or other emergency services right away if you have:
Call your doctor right away if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
Overuse of migraine drugs can cause rebound headaches. Rebound headaches are different from migraine headaches. They are usually triggered after pain medicine has worn off, prompting you to take another dose. Eventually you get a headache whenever you stop taking the drug. Be sure to take your migraine medicine only as prescribed by your doctor.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Last Revised: May 14, 2012
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