Methotrexate is typically given by injection. Two injection sites are sometimes used to administer one dose. This method increases absorption of all of the medicine.
Methotrexate treatment can be given as a single shot or as several injections. If an ectopic pregnancy continues after 2 or 3 doses of methotrexate, surgical treatment is needed to remove the ectopic pregnancy.
During the week that you have methotrexate injections, your pregnancy hormone levels (human chorionic gonadotropin, or hCG) are tested several times. Your doctor will look for a drop in hCG levels, which is a sign that the pregnancy is ending (hCG levels sometimes rise during the first few days of treatment, then drop).
Methotrexate series. Although it is an uncommon practice, methotrexate can be given every other day until pregnancy hormone (hCG) blood tests confirm that the pregnancy has ended. On alternate days, a medicine called leucovorin (folinic acid) is given by injection to reduce methotrexate side effects. Treatment time for a methotrexate series varies from case to case but can take a month or longer.
Methotrexate can be used to:
It is also used to treat certain types of cancer, rheumatoid arthritis, and as part of an induced abortion.
Methotrexate works as well as surgery (salpingostomy) for treating an ectopic pregnancy when:1
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine. Severe side effects from methotrexate are most likely to develop with long-term use, such as when it is used for cancer treatment.
Call 911 or other emergency services right away if you have:
Call your doctor if you have:
Common side effects include:
Rare side effects include:
Because of the risk of side effects, methotrexate treatment requires close medical supervision by a doctor who is experienced with this medicine. During methotrexate treatment, keep your doctor informed of any symptoms that you have.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
You will be advised to avoid the following until your treatment has finished:
Be safe with medicines. Read and follow all instructions on the label.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Last Revised: April 26, 2013
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