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Nitric Oxide

Uses

What Are Star Ratings?

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.

2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
Athletic Performance
4 gram three times per day
It has been speculated that AAKG may increase production of nitric oxide, a substance known to enhance blood flow. In one study, AAKG improved measures of strength and short-term power performance in weight lifters.
AAKG (arginine alpha-ketoglutarate) is a compound made from the amino acid L-arginine and alpha-ketoglutarate (AKG) a substance formed in the body’s energy-generating process. It has been speculated that AAKG may increase production in muscles of nitric oxide, a substance known to have blood-flow-enhancing effects. A double-blind study gave trained weight lifters either 4 grams of AAKG or a placebo three times a day during an eight-week weight-training regimen. AAKG had no effect on body composition but did improve measures of strength and short-term power performance.4

How It Works

How to Use It

Optimal levels remain unknown, though weight lifters were given 12 grams per day in one trial.

Where to Find It

Although the substances that comprise AAKG are present in many foods, the AAKG compound is found only in supplements.

Possible Deficiencies

A deficiency of AAKG has not been reported.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

In an eight-week double-blind trial, weight lifters taking 4 grams of AAKG three times a day reported no significant side effects, showed no changes in blood pressure or heart rate, and had no abnormalities on standard blood tests for general health.5 These athletes also reported no undesirable changes in general health, mental health, libido, sleep quality, or other quality of life measures.6 Some doctors believe that people with herpes (either cold sores or genital herpes) should not take arginine supplements, because of the possibility that arginine might stimulate replication of the virus.

No clear interactions between AAKG and other nutrients have been established.

References

1. Cylwik D, Mogielnicki A, Buczko W. L-arginine and cardiovascular system. Pharmacol Rep2005;57:14–22 [review].

2. Campbell B, Baer J, Roberts M, et al. Effects of arginine alpha-ketoglutarate supplementation on body composition and training adaptations. Sports Nutr Rev J 2004:1:S10 [abstract].

3. Campbell B, Roberts M, Kerksick C, et al. Pharmacokinetics, safety, and effects on exercise performance of l-arginine alpha-ketoglutarate in trained adult men. Nutrition2006;22:872–81.

4. Campbell B, Baer J, Roberts M, et al. Effects of arginine alpha-ketoglutarate supplementation on body composition and training adaptations. Sports Nutrition Review Journal 2004:1(1):S10 [abstract].

5. Vacanti T, Campbell B, Baer J, et al. Effects of arginine alpha-ketoglutarate supplementation on markers of catabolism and health status. Sports Nutr Rev J2004;1:S10–S11 [abstract].

6. Nassar EI, Bowden RG, Campbell B, et al. Effects of arginine alpha-ketoglutarate supplementation on quality of life. Sports Nutr Rev J 2004;1:S12–S13 [abstract].

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