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Methoxyisoflavone

Uses

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3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.

2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

This supplement has been used in connection with the following health conditions:

Used for Why
1 Star
Athletic Performance
Refer to label instructions
The developers of methoxyisoflavone, a member of the flavonoid family, claim that it builds bone and muscle without the side effects seen with hormones. One trial found that athletes who took it reduced their body fat more significantly than those taking placebo.
Methoxyisoflavone is a member of the family flavonoids (isoflavones). In a U.S. Patent, the developers of this substance claim, based on preliminary animal research, that it possesses anabolic (muscle-building and bone-building) effects without the side effects seen with either androgenic (male) hormones or estrogenic (female) hormones.2 A preliminary controlled trial found that strength-training athletes who took 800 mg per day of methoxyisoflavone for eight weeks experienced a significantly greater reduction in percentage body fat than those who took a placebo.3 Double-blind research is needed to confirm these findings. The U.S. patent also claims methoxyisoflavone reduces appetite and lowers blood cholesterol levels. Whether this claim is true has not yet been demonstrated in published scientific research.

How It Works

How to Use It

Manufacturers of methoxyisoflavone recommend 200 to 400 mg twice a day.

Where to Find It

Several substances similar to methoxyisoflavone are found in many plants and some foods, including soybeans. Whether methoxyisoflavone itself is found in nature is unknown.

Possible Deficiencies

Methoxyisoflavone is not an essential nutrient, so no deficiencies are possible.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

Hormones with anabolic effects on muscle often have side effects that include acne, male-pattern baldness, prostate enlargement, and lower high-density lipoprotein (HDL; “good”) cholesterol. Whether methoxyisoflavone can cause these side effects has not been investigated.

References

1. Feuer L, Farkas L, Nogradi M, et al. Metabolic 5-methyl-isoflavone-derivatives, process for the preparation thereof and compositions containing the same. United States Patent 4,163,746, August 7, 1979.

2. Feuer L, Farkas L, Nogradi M, et al. Metabolic 5-methyl-isoflavone-derivatives, process for the preparation thereof and compositions containing the same. United States Patent 4,163,746, August 7, 1979.

3. Incledon T, Gammeren DV, Antonio JA. The effects of 5-methylisoflavone on body composition and performance in college aged men. Med Sci Sports Exer 2001;33(5 suppl):S338 [abstract].

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