Some dieters say that 7-KETO helps promote weight loss, when used along with a diet and exercise program.
The ability of 7-KETO, a substance related to DHEA, to promote weight loss in overweight people has been investigated in one double-blind trial.1 Participants in the trial were advised to exercise three times per week for 45 minutes and to eat an 1,800-calorie-per-day diet. Each person was given either a placebo or 100 mg of 7-KETO twice daily. After eight weeks, those receiving 7-KETO had lost more weight and lowered their percentage of body fat further compared to those taking a placebo. These results may have been due to increases in levels of a thyroid hormone (T3) that plays a major role in determining a person’s metabolic rate, although the levels of T3 did not exceed the normal range.
A safety study in humans has shown that 7-KETO did not raise estrogen or testosterone levels or produce any other negative effects at levels up to 200 mg per day for eight weeks.2 Short-term animal studies also revealed no adverse effects with large amounts of 7-KETO.3 , 4 , 5 However, the long-term safety of 7-KETO for humans has not been demonstrated, and, because it is chemically related to steroid hormones, the potential for adverse effects must be considered. In addition, the increase in T3 levels resulting from taking 7-KETO could, in theory, produce adverse effects on the heart or promote bone loss. For these reasons, people wishing to take 7-KETO, particularly those who have a thyroid disorder or are taking thyroid hormone, should consult a physician.
7-KETO is available as a dietary supplement.
Last Review: 11-07-2012
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